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![GITRL, Soluble (mouse, rec.)](https://www.biomol.com/media/image/fe/4a/46/AG-40A-0008-C050_600x600.png)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
AG-40A-0008-C050 | 50 µg | - |
3 - 9 business days* |
330.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
The extracellular domain of mouse GITRL (amino acids 45-173) is fused at the N-terminus to a... more
Product information "GITRL, Soluble (mouse, rec.)"
The extracellular domain of mouse GITRL (amino acids 45-173) is fused at the N-terminus to a FLAG(R)-tag. Induces GITR-mediated NF-kappaB activation in HEK 293 cells. Liquid. 0.2µm-filtered solution in 10mM glycine, pH 10.0. GITRL (Glucocorticoid-induced TNF receptor ligand) is expressed on dendritic cells (DC), monocytes, macrophages, B cells, activated T cells, endothelial cells, osteoclasts and various healthy non-lymphoid tissues (e.g. testis). GITRL is constitutively expressed and released as soluble form by solid tumors and various hematopoietic malignancies. GITRL causes differentiation of osteoclasts, activation of macrophages, but also alteration of carcinoma and leukemia cells and influences apoptosis. Binding to GITR is important in regulating T cell proliferation and TCR-mediated apoptosis. GITRL is implicated in development of autoimmune diseases and in the immune response against infectious pathogens and tumors.
Keywords: | Glucocorticoid-induced TNF Receptor Ligand, AITRL, Activation-inducible TNF-related Ligand, TNFSF18 |
Supplier: | AdipoGen Life Sciences |
Supplier-Nr: | AG-40A-0008 |
Properties
Application: | Bioassays |
Conjugate: | No |
Host: | Human cells |
Species reactivity: | mouse |
MW: | 22 kD |
Format: | Liquid |
Database Information
KEGG ID : | K05479 | Matching products |
UniProt ID : | Q7TS55 | Matching products |
Gene ID | GeneID 240873 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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