Deoxyribonuclease gamma (Dnase1l3), mouse, recombinant

Deoxyribonuclease gamma (Dnase1l3), mouse, recombinant
Item number Size Datasheet Manual SDS Delivery time Quantity Price
CSB-EP007052MO.20 20 µg -

10 - 14 business days*

283.00€
CSB-EP007052MO.100 100 µg -

10 - 14 business days*

517.00€
CSB-EP007052MO.1 1 mg -

10 - 14 business days*

2,141.00€
 
Organism: Mus musculus (Mouse). Source: E.coli. Expression Region: 26-310aa. Protein Length: Full... more
Product information "Deoxyribonuclease gamma (Dnase1l3), mouse, recombinant"
Organism: Mus musculus (Mouse). Source: E.coli. Expression Region: 26-310aa. Protein Length: Full Length of Mature Protein. Tag Info: C-terminal 6xHis-tagged. Target Protein Sequence: LRLCSFNVRS FGASKKENHE AMDIIVKIIK RCDLILLMEI KDSSNNICPM LMEKLNGNSR RSTTYNYVIS SRLGRNTYKE QYAFVYKEKL VSVKTKYHYH DYQDGDTDVF SREPFVVWFH SPFTAVKDFV IVPLHTTPET SVKEIDELVD VYTDVRSQWK TENFIFMGDF NAGCSYVPKK AWQNIRLRTD PKFVWLIGDQ EDTTVKKSTS CAYDRIVLCG QEIVNSVVPR SSGVFDFQKA YDLSEEEALD VSDHFPVEFK LQSSRAFTNN RKSVSLKKRK KGNRS. Purity: Greater than 95% as determined by SDS-PAGE. Endotoxin: n/a. Biological Activity: n/a. Form: Liquid or Lyophilized powder. Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20 °C/-80 °C. Our default final concentration of glycerol is 50%. Customers could use it as reference. Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 °C/-80 °C. The shelf life of lyophilized form is 12 months at -20 °C/-80 °C. Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 °C for up to one week. Relevance: Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends. Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA. Acts in internucleosomal DNA fragmentation (INDF) during apoptosis and necrosis. The role in apoptosis includes myogenic and neuronal differentiation, and BCR-mediated clonal deletion of self-reactive B cells. Is active on chromatin in apoptotic cell-derived membrane-coated microparticles and thus suppresses anti-DNA autoimmunity. Together with DNASE1, plays a key role in degrading neutrophil extracellular traps (NETs). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation. Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation. Reference: n/a. Function: nan
Keywords: LSD, LS-DNase, EC=3.1.21.-, DNase gamma, DNase I-like 3, Liver and spleen DNase, Deoxyribonuclease gamma, Deoxyribonuclease I-like 3, DNase I homolog protein DHP2, Recombinant Mouse Deoxyribonuclease gamma (Dnase1l3)
Supplier: Cusabio
Supplier-Nr: EP007052MO

Properties

Application: Activity not tested
Conjugate: No
Host: E.coli
Species reactivity: mouse
MW: 40.1 kD
Purity: >95% (SDS-PAGE)

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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