Citrullinated Vimentin (human, recombinant)

Vimentin is a cytoskeleton intermediate filament protein present in cells of mesenchymal origin, including leukocytes, endothelial cells, and smooth muscle cells. It is subject to citrullination by peptidyl arginine deiminase 2 (PAD2, Cay-10785) under high calcium concentrations, which can occur during macrophage apoptosis. Citrullinated vimentin has been shown to have a role in the production of anti-citrullinated protein antibodies (ACPAs). ACPAs against citrullinated proteins, such as vimentin, are considered to be highly specific markers for rheumatoid arthritis and other autoimmune diseases.Purity: >55% estimated by SDS-PAGE. Protein Identity Confirmed by Mass Spec: Yes. Source: Human recombinant vimentin purified from E. coli. Amino Acids: 2-466. MW: 53.5 kDa. Formulation: (Request formulation change), 10 mM Tris, pH 8.0. UniProt Accession #: P08670.