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![CD40L, Soluble, Recombinant, Human (ACRP30headless:CD40L, ACRP30headless:CD154, ACRP30headless:TNFS](/custom/plugins/NetiThemeBiomol/Resources/Themes/Frontend/Biomol/frontend/_public/src/img/no-picture.jpg)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
044659.10 | 10 µg | - | - |
3 - 19 business days* |
568.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
CD40L is a high activity construct in which two trimeric CD40 ligands are artificially linked via... more
Product information "CD40L, Soluble, Recombinant, Human (ACRP30headless:CD40L, ACRP30headless:CD154, ACRP30headless:TNFS"
CD40L is a high activity construct in which two trimeric CD40 ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively simulates the natural membrane-assisted aggregation of CD40L in vivo. It provides a simple and equally potent alternative to combinations. CD40L has shown to suppress alum-induced IL-1beta release and caspase-1 activation in a dose-, CD40- and time dependent manner, without affecting BMDM viability. It also effectively suppressed the inflammasome function triggered by NLRP3 activators. The secretion of caspase-1 independent inflammatory mediators has been shown to be unaltered or even enhanced. Sequence: Human CD40L (aa116-261) is fused at the N-terminus to mouse ACRP30headless (aa18-111) and a FLAG(R)-tag, expressed in CHO cells. Biological Activity: Induces B cells activation (as demonstrated by dose-dependent upregulation of CD86) (ED50: <1ng/ml). Molecular Weight: ~35-40kD (SDS-PAGE), Endotoxin: <0.01EU/ug (LAL test, Lonza). Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: | CD40L, CD40LG |
Supplier: | United States Biological |
Supplier-Nr: | 044659 |
Properties
Conjugate: | No |
Species reactivity: | human |
Format: | Highly Purified |
Database Information
KEGG ID : | K03161 | Matching products |
UniProt ID : | P29965 | Matching products |
Gene ID | GeneID 959 | Matching products |
Handling & Safety
Storage: | vT |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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