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Track device being used
![CD279 [PD-1] (mouse):Fc (mouse) (rec.)](/custom/plugins/NetiThemeBiomol/Resources/Themes/Frontend/Biomol/frontend/_public/src/img/no-picture.jpg)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
CHI-MF-110PD1-C100 | 100 µg | - | - |
3 - 9 business days* |
429.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
The extracellular domain of mouse CD279 [PD-1] (aa 26-169) is fused to the N-terminus of the Fc... more
Product information "CD279 [PD-1] (mouse):Fc (mouse) (rec.)"
The extracellular domain of mouse CD279 [PD-1] (aa 26-169) is fused to the N-terminus of the Fc region of mouse IgG2a. CD279 (Programmed Cell Death Protein 1, PD-1) is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA-4 family have been shown to either promote T cell activation (CD28 and ICOS) or downregulate T cell activation (CTLA-4 and PD-1). CD279 is expressed on activated T cells, B cells, myeloid cells and on a subset of thymocytes. In vitro, ligation of CD279 inhibits TCR-mediated T cell proliferation and production of IL-1, IL-4, IL-10 and IFN-?. In addition, CD279 ligation also inhibits BCR mediated signaling. CD279 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases.
Keywords: | Pd1, CD279, mPD-1, Pdcd1, Protein PD-1, Programmed cell death protein 1 |
Supplier: | Chimerigen Laboratories |
Supplier-Nr: | MF-110PD1 |
Properties
Application: | Bioassays |
Conjugate: | No |
Host: | Hamster cells |
Species reactivity: | mouse |
Purity: | >98% |
Format: | Lyophilized |
Database Information
KEGG ID : | K06744 | Matching products |
UniProt ID : | Q02242 | Matching products |
Gene ID | GeneID 18566 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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