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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
E-PDEM100044.20 | 20 µg | - |
7 - 16 business days* |
81.00€
|
|||
E-PDEM100044.100 | 100 µg | - |
7 - 16 business days* |
141.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Activity: Testing in progress Protein Construction: A DNA sequence encoding the Mouse CASP8... more
Product information "Caspase-8/CASP8 protein (His tag), recombinant mouse"
Activity: Testing in progress Protein Construction: A DNA sequence encoding the Mouse CASP8 protein (O89110) (Ser219-Gly376) was expressed with a N-His . Sequence: Ser 219-Gly 376. Fusion tag: N-His Endotoxin: Please contact us for more information. Apparent Molecular Mass: 20 kDa. Protein function: Caspase-8 (Cysteine-aspartic acid protease 8/Casp8a, also named MCH5, FLICA and MACH alpha 1) is a 28 kDa member of the peptidase C14A family of enzymes. It is widely expressed and is considered an initiating caspase for the apoptotic cascade. Caspase-8 a Protein function: Thiol protease that plays a key role in programmed cell death by acting as a molecular switch for apoptosis, necroptosis and pyroptosis, and is required to prevent tissue damage during embryonic development and adulthood (PubMed:12065591, PubMed:18455983, PubMed:30361383, PubMed:30381458, PubMed:31511692, PubMed:31748744, PubMed:33397971). Initiator protease that induces extrinsic apoptosis by mediating cleavage and activation of effector caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death (PubMed:9654089, PubMed:9837723, PubMed:24813849, PubMed:24813850). Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. Binding to the adapter molecule FADD recruits it to either receptor TNFRSF6/FAS mediated or TNFRSF1A (PubMed:29440439). The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. In addition to extrinsic apoptosis, also acts as a negative regulator of necroptosis: acts by cleaving RIPK1 at 'Asp-325', which is crucial to inhibit RIPK1 kinase activity, limiting TNF-induced apoptosis, necroptosis and inflammatory response (PubMed:31511692). Also able to initiate pyroptosis by mediating cleavage and activation of gasdermin-D (GSDMD): GSDMD cleavage promoting release of the N-terminal moiety (Gasdermin-D, N-terminal) that binds to membranes and forms pores, triggering pyroptosis (PubMed:30361383, PubMed:30381458). Initiates pyroptosis following inactivation of MAP3K7/TAK1 (PubMed:30361383, PubMed:30381458). Also acts as a regulator of innate immunity by mediating cleavage and inactivation of N4BP1 downstream of TLR3 or TLR4, thereby promoting cytokine production (PubMed:32971525). May participate in the Granzyme B (GZMB) cell death pathways. Cleaves PARP1 and PARP2 (PubMed:12065591). [The UniProt Consortium]
Keywords: | , Recombinant Mouse Caspase-8/CASP8 protein (His tag) |
Supplier: | Elabscience |
Supplier-Nr: | E-PDEM100044 |
Properties
Conjugate: | No |
Host: | E.coli |
Species reactivity: | mouse |
MW: | 17.27 kD |
Format: | Lyophilized |
Database Information
KEGG ID : | K04398 | Matching products |
UniProt ID : | O89110 | Matching products |
Gene ID | GeneID 12370 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | 4°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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