Carbamylated Bovine Serum Albumin

Citrullination and carbamylation are two post-translational modifications that result in the generation of citrulline and homocitrulline, two highly related, non-standard amino acids. While citrullination of arginine is catalyzed by peptidylarginine deiminases (PADs), homocitrulline results from the non-enzymatic reaction of cyanate with lysine. Carbamylation occurs at low levels in healthy individuals, but at higher levels in several clinical conditions such as atherosclerosis, kidney disease, and inflammation. Carbamylation can lead to changes in protein function, cellular function, and generation of an immune response to homocitrulline containing proteins. This product contains carbamylated bovine serum albumin.Synonyms: Ca-BSA, Carbamylated BSA. Purity: >85% estimated by SDS-PAGE. Source: Albumin isolated from bovine plasma and modified with potassium cyanate. MW: 69.3 kDa. Formulation: (Request formulation change), Lyophilized from a solution in PBS, pH 7.4.