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![B7-H4 (human):Fc (human) (rec.)](/custom/plugins/NetiThemeBiomol/Resources/Themes/Frontend/Biomol/frontend/_public/src/img/no-picture.jpg)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
CHI-HF-210B7H4-C100 | 100 µg | - | - |
3 - 9 business days* |
457.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
The extracellular domain of human B7-H4 (aa 29-258) is fused to the N-terminus of the Fc region... more
Product information "B7-H4 (human):Fc (human) (rec.)"
The extracellular domain of human B7-H4 (aa 29-258) is fused to the N-terminus of the Fc region of human IgG1. Lyophilized from 0.2µm-filtered solution in PBS. B7H4 is a B7 family member that negatively regulates T cell immunity by inhibiting of T cell proliferation, cytokine production, and cell cycle progression. In vitro, B7H4 inhibits CD4 and CD8 T cell proliferation, cytokine production, and generation of alloreactive cytotoxic T-cells (CTLs). In vivo, blockade of endogenous B7-H4 by specific monoclonal antibody promotes T cell responses. B7-H4 ia an important negative regulator of innate immunity through growth inhibition of neutrophils. B7-H4 is expressed on some tumor cancer cells. The role of B7-H4 in tumor progression may be to transform precancerous cells and then protect them from immunosurveillance.
Keywords: | B7h.5, Protein B7S1, T-cell costimulatory molecule B7x, Immune costimulatory protein B7-H4, V-set domain-containing T-cell activation inhibitor 1 |
Supplier: | Chimerigen Laboratories |
Supplier-Nr: | HF-210B7H4 |
Properties
Application: | Bioassays |
Conjugate: | No |
Host: | Hamster cells |
Species reactivity: | human |
Purity: | >98% |
Format: | Lyophilized |
Database Information
KEGG ID : | K06747 | Matching products |
UniProt ID : | Q7Z7D3 | Matching products |
Gene ID | GeneID 79679 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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