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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
009-001-E75 | 10 µg | - | - |
6 - 10 business days* |
454.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Recombinant protein corresponds to amino acids 1 to 481 of mature human AKT3, Akt isoform 3. The... more
Product information "AKT3 (phosphatase treated) Human Recombinant Protein"
Recombinant protein corresponds to amino acids 1 to 481 of mature human AKT3, Akt isoform 3. The recombinant protein contains a polyhistidine affinity tag at the amino terminus. Purity is greater than 90% as determined by reducing and non-reducing SDS-PAGE and by analytical HPLC. Protein function: AKT3 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase- dependent apoptosis. [The UniProt Consortium]
Keywords: | PKBG, AKT3, STK-2, PKB gamma, EC=2.7.11.1, RAC-PK-gamma, Protein kinase Akt-3, Protein kinase B gamma, RAC-gamma serine/threonine-protein kinase |
Supplier: | Rockland Immunochemicals |
Supplier-Nr: | 009-001-E75 |
Properties
Application: | WB |
Conjugate: | No |
Host: | Insect cells |
Species reactivity: | human |
Database Information
KEGG ID : | K04456 | Matching products |
UniProt ID : | Q9Y243 | Matching products |
Gene ID : | GeneID 10000 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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