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![5HT2C (human) full length protein-synthetic nanodisc](/custom/plugins/NetiThemeBiomol/Resources/Themes/Frontend/Biomol/frontend/_public/src/img/no-picture.jpg)
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Larger quantity required? Request bulk
Discover a breakthrough in membrane protein research and drug development with DIMA Biotech's... more
Product information "5HT2C (human) full length protein-synthetic nanodisc"
Discover a breakthrough in membrane protein research and drug development with DIMA Biotech's Synthetic Nanodiscs. Traditional methods struggle with challenges in obtaining water-soluble and bioactive forms of multi-transmembrane proteins. Our innovative polymer-based Nanodisc platform offers a game-changing solution by excluding membrane scaffold proteins (MSPs), resulting in a cleaner system with fewer interferences for downstream assays. By disassembling cell membranes into nanoscale disc-shaped structures, our technology enables the purification of membrane proteins to high homogeneity under aqueous conditions. Explore how Synthetic Nanodiscs empower the functional characterization of multi-span transmembrane proteins in their active form, revolutionizing the future of membrane protein research and drug development. Protein function: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,- dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and eating behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis. [The UniProt Consortium]
Keywords: | HTR1C, HTR2C, 5-HT1C, 5-HT2C, 5-HT-2C, 5-HT-1C, 5-HTR2C, Serotonin receptor 2C, 5-hydroxytryptamine receptor 1C, 5-hydroxytryptamine receptor 2C, 5-HT1C, 5-HT2C, 5-HTR2C, 5HTR2C, HTR1C, Human 5HT2C full length protein-synthetic nanodisc |
Supplier: | DIMA |
Supplier-Nr: | FLP100168 |
Properties
Application: | Full length transmembrane protein, FA, ELISA, screening, immunization, cell-based assays, crystallization |
Conjugate: | No |
Host: | Human cells |
Species reactivity: | human |
MW: | 51.8 kD |
Format: | Lyophilized |
Database Information
KEGG ID : | K04157 | Matching products |
UniProt ID : | P28335 | Matching products |
Gene ID | GeneID 3358 | Matching products |
Handling & Safety
Storage: | -20°C (avoid repeat freezing and thawing cycles) |
Shipping: | +20°C (International: +20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
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