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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Organism: Oryctolagus cuniculus (Rabbit). Source: E.coli. Expression Region: 106-529aa. Protein... more
Product information "4F2 cell-surface antigen heavy chain (SLC3A2), partial, rabbit, recombinant"
Organism: Oryctolagus cuniculus (Rabbit). Source: E.coli. Expression Region: 106-529aa. Protein Length: Partial. Tag Info: C-terminal 6xHis-tagged. Target Protein Sequence: RAPRCRELPV QRWWHKGALY RVGDLQAFQA RDSGDLAGLK GHLDYLSTLK VKGLVLGPIH KNQEDDVAGT NLQEINPAVG SKEEFDSFLQ SAKKKSIRVI LDLTPNYLGQ NSWFLPTQVD LVATKVKDAL NFWLQAGVDG FQVRDVGNLT NAALHLAEWR NITKSFSEDR LLIAGTESSD LHQILSLLES TKDLLLTSSY LSASGVSGEN MKFLVTQYLN ATDSHWCSWS LSQAGLLTSF VPAQLLRLYQ LLLFTLPGTP VFSYGDEIGL QAAALPGEPA KAPVMLWDES SLPSASVSAN MTVKGQDEDS GSLLSLFRRL SDQRGKERSL LHGDFHALST GSNLFSYVRH WDQNERFLVV LNFGDESLSA RLGASSLPAG ASLPARADLL LSTHPGREEG TSLALEHLNL EPHEGLLLHF PYVA. Purity: Greater than 85% as determined by SDS-PAGE. Endotoxin: n/a. Biological Activity: n/a. Form: Liquid or Lyophilized powder. Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20 °C/-80 °C. Our default final concentration of glycerol is 50%. Customers could use it as reference. Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 °C/-80 °C. The shelf life of lyophilized form is 12 months at -20 °C/-80 °C. Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 °C for up to one week. Relevance: Component of several heterodimeric complexes involved in amino acid transport. The precise substrate specificity depends on the other subunit in the heterodimer. The complexes function as amino acid exchangers. The homodimer functions as sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, L-DOPA, leucine, histidine, methionine and tryptophan. The heterodimer formed by SLC3A2 and SLC7A6 or SLC3A2 and SLC7A7 mediates the uptake of dibasic amino acids. The heterodimer with SLC7A5/LAT1 mediates the transport of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane. The heterodimer with SLC7A5/LAT1 is involved in the uptake of toxic methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes. The heterodimer with SLC7A5/LAT1 is involved in the uptake of leucine. When associated with LAPTM4B, the heterodimer with SLC7A5/LAT1 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation. The heterodimer with SLC7A5/LAT1 may play a role in the transport of L-DOPA across the blood-brain barrier. The heterodimer formed by SLC3A2 and SLC7A5/LAT1 or SLC3A2 and SLC7A8/LAT2 is involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1, regulates the transport activity of SLC7A8/LAT2 in polarized intestinal cells by generating and delivering intracellular signals. Required for targeting of SLC7A5/LAT1 and SLC7A8/LAT2 to the plasma membrane and for channel activity. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. May mediate blood-to-retina L-leucine transport across the inner blood-retinal barrier. Reference: n/a. Function: nan
Keywords: | CD98, 4F2hc, Solute carrier family 3 member 2, 4F2 cell-surface antigen heavy chain, Amino acid transporter heavy chain SLC3A2, Recombinant Rabbit 4F2 cell-surface antigen heavy chain (SLC3A2), partial |
Supplier: | Cusabio |
Supplier-Nr: | EP800072RB |
Properties
Application: | Activity not tested |
Conjugate: | No |
Host: | E.coli |
Species reactivity: | rabbit |
MW: | 53.5 kD |
Purity: | >85% (SDS-PAGE) |
Database Information
KEGG ID : | K06519 | Matching products |
UniProt ID : | Q7YQK3 | Matching products |
Gene ID : | GeneID 100009363 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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