Z-D-Arg-Gly-Arg-pNA (hydrochloride)

Z-D-Arg-Gly-Arg-pNA is a colorimetric substrate for Factor Xa. Factor Xa preferentially binds to and cleaves the Arg-Gly-Arg (RGR) peptide sequence to release p-nitroanilide (pNA), which can be quantified by colorimetric detection at 405 nm as a measure of Factor Xa activity.Formal Name: N2-[(phenylmethoxy)carbonyl]-D-arginylglycyl-N-(4-nitrophenyl)-L-argininamide, dihydrochloride. CAS Number: 113711-77-6. Synonyms: Benzyl-D-Arg-Gly-Arg-pNA, Benzyl-D-Arg-Gly-Arg-p-nitroanilide, Factor Xa Chromogenic Substrate, S-2765. Molecular Formula: C28H39N11O7 . 2HCl. Formula Weight: 714.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 14 mg/ml, DMSO: 14 mg/ml, Ethanol: partially soluble, PBS (pH 7.2): 0.5 mg/ml. lambdamax: 315 nm. SMILES: O=C([C@H](CCCNC(N)=N)NC(CNC([C@@H](CCCNC(N)=N)NC(OCC1=CC=CC=C1)=O)=O)=O)NC2=CC=C([N+]([O-])=O)C=C2.Cl.Cl. InChi Code: InChI=1S/C28H39N11O7.2ClH/c29-26(30)33-14-4-8-21(38-28(43)46-17-18-6-2-1-3-7-18)24(41)35-16-23(40)37-22(9-5-15-34-27(31)32)25(42)36-19-10-12-20(13-11-19)39(44)45,,/h1-3,6-7,10-13,21-22H,4-5,8-9,14-17H2,(H,35,41)(H,36,42)(H,37,40)(H,38,43)(H4,29,30,33)(H4,31,32,34),2*1H/t21-,22+,,/m1../s1. InChi Key: SSYLORYZHRLKBF-ZZYOSWMOSA-N.