Plipastatin A1

Plipastatin A1 is a lipopeptide that has been found in B. cereus and has enzyme inhibitory and immunosuppressant activities. It inhibits phospholipase A2 (PLA2), PLC, and PLD (IC50s = 2.9, 1.3, and 1.4 µM, respectively). Plipastatin A1 (100 µg/ml) inhibits LPS-induced B cell blastogenesis and T cell blastogenesis induced by concanavalin A (Cay-14951). In vivo, plipastatin A1 (0.1 mg/animal) inhibits delayed-type hypersensitivity in mice.Formal Name: (10->3)-lactone, N-[(3R)-3-hydroxy-1-oxohexadecyl]-L-alpha-glutamyl-D-ornithyl-L-tyrosyl-D-allothreonyl-L-alpha-glutamyl-prolyl-L-glutaminyl-D-tyrosyl-L-isoleucine. CAS Number: 103651-09-8. Synonyms: Fengycin IX, SNA-60-367-3. Molecular Formula: C72H110N12O20. Formula Weight: 1463.7. Purity: >90%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Methanol: Soluble, Water: Soluble. SMILES: O=C([C@H](NC([C@@H](NC(C[C@@H](CCCCCCCCCCCCC)O)=O)CCC(O)=O)=O)CCCN)N[C@@H](CC1=CC=C(OC([C@@]([C@@H](C)CC)([H])NC([C@@H](CC2=CC=C(O)C=C2)NC3=O)=O)=O)C=C1)C(N[C@@]([C@H](O)C)([H])C(N[C@@H](CCC(O)=O)C(N[C@H](C)C(N4[C@@](C(N[C@H]3CCC(N)=O)=O)([H])CCC4)=O)=O)=O)=O. InChi Code: InChI=1S/C72H110N12O20/c1-6-8-9-10-11-12-13-14-15-16-17-20-48(87)41-58(89)76-51(32-35-59(90)91)65(96)77-50(21-18-37-73)64(95)80-55-40-46-25-29-49(30-26-46)104-72(103)61(42(3)7-2)82-67(98)54(39-45-23-27-47(86)28-24-45)81-66(97)52(31-34-57(74)88)78-69(100)56-22-19-38-84(56)71(102)43(4)75-63(94)53(33-36-60(92)93)79-70(101)62(44(5)85)83-68(55)99/h23-30,42-44,48,50-56,61-62,85-87H,6-22,31-41,73H2,1-5H3,(H2,74,88)(H,75,94)(H,76,89)(H,77,96)(H,78,100)(H,79,101)(H,80,95)(H,81,97)(H,82,98)(H,83,99)(H,90,91)(H,92,93)/t42-,43+,44+,48+,50+,51-,52-,53-,54+,55-,56-,61-,62+/m0/s1. InChi Key: CUOJDWBMJMRDHN-VIHUIGFUSA-N. Origin: Bacterium/Bacillus sp..