Gly-Pro-pNA (hydrochloride)

Gly-Pro-pNA is a chromogenic substrate that can be cleaved by the circulating enzyme, dipeptidyl peptidase IV (DPP IV). Enzyme activity can be quantified by colorimetric detection of free p-nitroanilide at 405 nm. DPP IV inactivates the two peptides responsible for a majority of nutrient-stimulated insulin secretion: glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1). This substrate can be used to screen for DPP IV inhibitors, which have emerged as a new class of experimental antidiabetic agents.Formal Name: glycyl-N-(4-nitrophenyl)-L-prolinamide, monohydrochloride. CAS Number: 103213-34-9. Synonyms: Gly-Pro p-nitroanilide, GP-pNA. Molecular Formula: C13H16N4O4 . HCl. Formula Weight: 328.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 221, 312 nm. SMILES: O=C(CN)N1CCC[C@H]1C(NC2=CC=C([N+]([O-])=O)C=C2)=O.Cl. InChi Code: InChI=1S/C13H16N4O4.ClH/c14-8-12(18)16-7-1-2-11(16)13(19)15-9-3-5-10(6-4-9)17(20)21,/h3-6,11H,1-2,7-8,14H2,(H,15,19),1H/t11-,/m0./s1. InChi Key: VBBFIBMVFSUUBP-MERQFXBCSA-N.