EPI-X4 (trifluoroacetate salt)

EPI-X4 is an endogenous peptide fragment corresponding to amino acids 408-423 of human serum albumin and an antagonist of chemokine (C-X-C motif) receptor 4 (CXCR4). It inhibits calcium mobilization and receptor internalization induced by chemokine (C-X-C motif) ligand 12 (CXCL12) in HEK293 cells expressing CXCR4 when used at concentrations ranging from 0.8 to 1,000 µM. EPI-X4 inhibits CXCL12-induced migration of Jurkat T cells and human CD34+ hematopoietic stem cells. In vivo, EPI-X4 (16 µmol/kg) reduces Cxcr4-dependent inflammatory cell airway infiltration in a mouse model of acute allergic airway hypereosinophilia. Urinary levels of EPI-X4 are increased and inversely correlated with glomerular filtration rate (GFR) in patients with chronic kidney disease.Formal Name: L-leucyl-L-valyl-L-arginyl-L-tyrosyl-L-threonyl-L-lysyl-L-lysyl-L-valyl-L-prolyl-L-glutaminyl-L-valyl-L-seryl-L-threonyl-L-prolyl-L-threonyl-L-leucine, trifluoroacetate salt. Synonyms: Endogenous Peptide Inhibitor of CXCR4. Molecular Formula: C84H144N22O23 . XCF3COOH. Formula Weight: 1830.2. Purity: >98%. Formulation: (Request formulation change), A solid. Peptide Sequence: LVRYTKKVPQVSTPTL-OH. Solubility: Ethanol: Soluble, Methanol: Soluble. SMILES: [H]N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@]([C@@H](C)O)([H])C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N1CCC[C@H]1C(N[C@@H](CCC(N)=O)C(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@]([C@@H](C)O)([H])C(N2CCC[C@H]2C(N[C@]([C@@H](C)O)([H])C(N[C@@H](CC(C)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC3=CC=C(O)C=C3)=O)=O)=O.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C84H144N22O23.C2HF3O2/c1-41(2)37-51(87)68(113)99-62(43(5)6)77(122)94-54(23-18-34-91-84(89)90)70(115)96-56(39-49-26-28-50(111)29-27-49)73(118)102-65(46(11)108)79(124)95-52(21-14-16-32-85)69(114)92-53(22-15-17-33-86)71(116)101-64(45(9)10)81(126)105-35-19-24-59(105)75(120)93-55(30-31-61(88)112)72(117)100-63(44(7)8)78(123)98-58(40-107)74(119)104-67(48(13)110)82(127)106-36-20-25-60(106)76(121)103-66(47(12)109)80(125)97-57(83(128)129)38-42(3)4,3-2(4,5)1(6)7/h26-29,41-48,51-60,62-67,107-111H,14-25,30-40,85-87H2,1-13H3,(H2,88,112)(H,92,114)(H,93,120)(H,94,122)(H,95,124)(H,96,115)(H,97,125)(H,98,123)(H,99,113)(H,100,117)(H,101,116)(H,102,118)(H,103,121)(H,104,119)(H,128,129)(H4,89,90,91),(H,6,7)/t46-,47-,48-,51+,52+,53+,54+,55+,56+,57+,58+,59+,60+,62+,63+,64+,65+,66+,67+,/m1./s1. InChi Key: QNWPJTGVDNPULA-QXIRNSRISA-N.