Antipain . dihydrochloride

White to off-white solid. Soluble in water, ethanol, methanol, DMSO or acetonitrile. Potent reversible inhibitor of serine/cysteine proteases and some trypsin-like proteases. Inhibits papain, trypsin and trypsin-like serine proteases as well as cathepsin A, B and D, Similar activity spectrum comparable to leupeptin (AG-CP3-7000), Acts by forming a hemiacetal adduct between its aldehyde group and the active serine of the proteinase, Inhibits transformation of NIH3T3 cells after transfection with an activated H-ras oncogene, Used to evaluate the role of proteases in the process of malignant cell transformations, Shows antibacterial and antiparasitic activity.