Z-Asp-CH2-DCB

Z-Asp-CH2-DCB is a peptide originally synthesized for its ability to inactivate the interleukin-1beta-converting enzyme, which is the homolog of the C. elegans positive regulator of apoptosis CED-3. Z-Asp-CH2-DCB has been shown to block apoptosis by nonselectively inhibiting caspase activity. At 1-100 µM, it can dose-dependently block the production of IL-1beta, TNF-alpha, IL-6, and IFN-gamma by human peripheral blood mononuclear cells as well as inhibit T cell proliferation.Formal Name: (3S)-4-carboxy-2-oxo-3-[[(phenylmethoxy)carbonyl]amino]butyl ester 2,6-dichloro-benzoic acid. CAS Number: 153088-73-4. Synonyms: Z-Asp-2,6-Dichlorobenzoyloxymethyl Ketone. Molecular Formula: C20H17Cl2NO7. Formula Weight: 454.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 25 mg/ml, Ethanol: 33 mg/ml, Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml. SMILES: ClC1=C(C(OCC([C@@H](NC(OCC2=CC=CC=C2)=O)CC(O)=O)=O)=O)C(Cl)=CC=C1. InChi Code: InChI=1S/C20H17Cl2NO7/c21-13-7-4-8-14(22)18(13)19(27)29-11-16(24)15(9-17(25)26)23-20(28)30-10-12-5-2-1-3-6-12/h1-8,15H,9-11H2,(H,23,28)(H,25,26)/t15-/m0/s1. InChi Key: FKJMFCOMZYPWCO-HNNXBMFYSA-N.