Valsartan-d9

Valsartan-d9 is intended for use as an internal standard for the quantification of valsartan (Cay-14178) by GC- or LC-MS. Valsartan is a nonpeptide antagonist of the angiotensin II type 1 (AT1) receptor (IC50 = 2.7 nM). It is 20,000-fold selective for AT1 over AT2 and, unlike some other AT receptor antagonists, does not alter peroxisome proliferator-activated receptor gamma (PPARgamma) activity in vitro. In vivo, valsartan (30 mg/kg) increases cardiac output and reduces left ventricular fibrosis in a model of heart failure with reduced ejection fraction in mice with streptozotocin-induced diabetes. Formulations containing valsartan have been used in the treatment of hypertension and heart failure.Formal Name: N-(1-oxopentyl-2,2,3,3,4,4,5,5,5-d9)-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-valine. CAS Number: 1089736-73-1. Synonyms: CGP 48933-d9. Molecular Formula: C24H20D9N5O3. Formula Weight: 444.6. Purity: >99% deuterated forms (d1-d9). Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml. SMILES: O=C(C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])N([C@@](C(O)=O)([H])C(C)C)CC1=CC=C(C2=CC=CC=C2C3=NNN=N3)C=C1. InChi Code: InChI=1S/C24H29N5O3/c1-4-5-10-21(30)29(22(16(2)3)24(31)32)15-17-11-13-18(14-12-17)19-8-6-7-9-20(19)23-25-27-28-26-23/h6-9,11-14,16,22H,4-5,10,15H2,1-3H3,(H,31,32)(H,25,26,27,28)/t22-/m0/s1/i1D3,4D2,5D2,10D2. InChi Key: ACWBQPMHZXGDFX-KDDXQTGLSA-N.