SN50 TFA

Description: SN50 TFA is a cell-permeable inhibitor of NF-kappaB and attenuates alveolar hypercoagulation and fibrinolysis inhibition in acute respiratory distress syndrome mice through inhibiting NF-kappaB p65 translocation. SN50 TFA can be used in studies about ARDS. Target: NF-kappaB. Smiles: [H]N[C@H](C(N[C@H](C(N[C@@H](C(C)C)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N1CCC[C@H]1C(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@H](C(N2CCC[C@H]2C(N[C@@H](C(C)C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@H](C(N3CCC[C@H]3C(O)=O)=O)CCSC)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)C)=O)=O)=O)=O)C)=O)=O)=O)=O)C)=O)=O)C)=O)C.OC(C(F)(F)F)=O. References: Lin, Y.Z., Tao, S., Veach, R.A., et al.Inhibition of nuclear translocation of transcription factor NF-kappaB by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequenceJ. Biol. Chem.270(24)14255-14258(1995)