RO27-3225 (trifluoroacetate salt)

RO27-3225 is a peptide agonist of melanocortin receptor 4 (MC4R). It selectively induces cAMP production in cells expressing human MC4R (EC50 = 0.3 nM) over cells expressing MC1R, MC3R, or MC5R (EC50s = 1.1, 97.9, and 139.4 nM, respectively). In vivo, RO27-3225 (3, 5, and 10 nmol/animal) reduces food intake in rats, as well as in obese db/db mice when administered at a dose of 200 µg/animal. RO27-3225 also reduces brain edema, blood-brain barrier (BBB) permeability, and hippocampal Il-1beta and Tnf-alpha levels in a rat model of intra-abdominal hypertension induced by hemorrhagic shock and resuscitation.Formal Name: N-(1-oxobutyl)-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-N2-methyl-glycinamide, trifluoroacetate salt. CAS Number: 1373926-49-8. Synonyms: Oxobutyl-His-Phe-Arg-Trp-{Sar}-NH2. Molecular Formula: C39H52N12O6 . XCF3COOH. Formula Weight: 784.9. Purity: >98%. Formulation: (Request formulation change), A solid. Peptide Sequence: Oxobutyl-HFRWX-NH2 (X=Sarcosine). Solubility: :, DMSO: Soluble: >10 mg/ml, Ethanol: Sparingly soluble: 1-10 mg/ml, PBS (pH 7.2): Sparingly soluble: 1-10 mg/ml. SMILES: OC(C(F)(F)F)=O.CCCC(N[C@@H](CC1=CN=CN1)C(N[C@H](CC2=CC=CC=C2)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N(C)CC(N)=O)=O)CC3=CNC4=CC=CC=C34)=O)=O)=O)=O. InChi Code: InChI=1S/C39H52N12O6.C2HF3O2/c1-3-10-34(53)47-31(19-26-21-43-23-46-26)37(56)49-30(17-24-11-5-4-6-12-24)36(55)48-29(15-9-16-44-39(41)42)35(54)50-32(38(57)51(2)22-33(40)52)18-25-20-45-28-14-8-7-13-27(25)28,3-2(4,5)1(6)7/h4-8,11-14,20-21,23,29-32,45H,3,9-10,15-19,22H2,1-2H3,(H2,40,52)(H,43,46)(H,47,53)(H,48,55)(H,49,56)(H,50,54)(H4,41,42,44),(H,6,7)/t29-,30+,31-,32-,/m0./s1. InChi Key: XBNXUPIBUGBMCO-KQQVHNFSSA-N.