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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay24126-1 | 1 mg | - |
6 - 10 business days* |
270.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Pam3CSK4 is a synthetic bacterial lipopeptide that binds to and acts as an agonist at toll-like... more
Product information "Pam3CSK4 (trifluoroacetate salt)"
Pam3CSK4 is a synthetic bacterial lipopeptide that binds to and acts as an agonist at toll-like receptor 2 (TLR2). It induces proliferation of isolated mouse spleen cells and activates lymphocytes at a concentration of 50 µg/ml. Pam3CSK4 is a potent immune adjuvant in mice, enhancing the response to antigen, as measured by IgM and IgG levels, when used at a dose of 200 µg/animal. It inhibits Th1 and Th2 responses, suppresses eosinophil infiltration, and induces CD4+ T cell apoptosis in a mouse model of allergic conjunctivitis. Pam3CSK4 (50 µg) decreases lesion size and parasite burden in genetically-resistant and -susceptible mice when administered with L. major to induce leishmaniasis. It also enhances Th1 responses and stimulates IL-17 production in the early phase of infection.Formal Name: S-[2,3-bis[(1-oxohexadecyl)oxy]propyl]-N-(1-oxohexadecyl)-L-cysteinyl-L-seryl-L-lysyl-L-lysyl-L-lysyl-L-lysine, trifluoroacetate salt. Synonyms: Pam3Cys-Ser-(Lys)4. Molecular Formula: C81H156N10O13S . XCF3COOH. Formula Weight: 1510.2. Purity: >95%. Formulation: (Request formulation change), A lyophilized powder. Solubility: Formic Acid: 1 mg/ml. SMILES: O=C(N[C@@H](CCCCN)C(N[C@H](C(O)=O)CCCCN)=O)[C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CO)NC([C@@H](NC(CCCCCCCCCCCCCCC)=O)CSCC(OC(CCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O)=O)=O)=O.FC(F)(C(O)=O)F. InChi Code: InChI=1S/C81H156N10O13S.C2HF3O2/c1-4-7-10-13-16-19-22-25-28-31-34-37-40-55-73(93)86-72(65-105-64-66(104-75(95)57-42-39-36-33-30-27-24-21-18-15-12-9-6-3)63-103-74(94)56-41-38-35-32-29-26-23-20-17-14-11-8-5-2)80(100)91-71(62-92)79(99)89-68(52-44-48-59-83)77(97)87-67(51-43-47-58-82)76(96)88-69(53-45-49-60-84)78(98)90-70(81(101)102)54-46-50-61-85,3-2(4,5)1(6)7/h66-72,92H,4-65,82-85H2,1-3H3,(H,86,93)(H,87,97)(H,88,96)(H,89,99)(H,90,98)(H,91,100)(H,101,102),(H,6,7)/t66?,67-,68-,69-,70-,71-,72-,/m0./s1. InChi Key: VUABEPVGXYOKOG-UDFJXRDYSA-N.
Keywords: | Pam3Cys-Ser-(Lys)4, S-[2,3-bis[(1-oxohexadecyl)oxy]propyl]-N-(1-oxohexadecyl)-L-cysteinyl-L-seryl-L-lysyl-L-lysyl-L-lysyl-L-lysine, trifluoroacetate salt |
Supplier: | Cayman Chemical |
Supplier-Nr: | 24126 |
Properties
Application: | TLR2 agonist |
Conjugate: | No |
MW: | 1510.2 D |
Formula: | C81H156N10O13S . XCF3COOH |
Purity: | >95% |
Format: | Solid |
Database Information
KEGG ID : | K10159 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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