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Description: Oleoyl proline is an N-acyl amine that can be detected in bovine brain extracts and D. melanogaster larvae using mass spectrometry. In a preclinical model of pain, mice lacking fatty acid amide hydrolase (FAAH KO) had decreased N-oleoyl proline levels in the lumbar spinal cord after capsaicin administration (1 µg/10 µl). Smiles: C(CCCCCCC/C=C\CCCCCCCC)(=O)N1[C@H](C(O)=O)CCC1. References: Hong K, Zhao G, Hong Z, Sun Z, Yang Y, Clifford PS, Davis MJ, Meininger GA, Hill MA. Mechanical activation of angiotensin II type 1 receptors causes actin remodelling and myogenic responsiveness in skeletal muscle arterioles. J Physiol. 2016 Dec 1,594(23):7027-7047. doi: 10.1113/JP272834. Epub 2016 Oct 13. PubMed PMID: 27531064, PubMed Central PMCID: PMC5134373.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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