NF023 hexasodium

Description: NF023 hexasodium is a selective and competitive P2X1 receptor antagonist with IC50 values of 0.21 µM, 28.9 µM, > 50 µM, and > 100 µM for human [P2X1], [P2X3], [P2X2], and [P2X4]-mediated responses, respectively. Target: P2X Receptor. Smiles: O=C(NC1=CC=CC(C(NC2=C3C(S(=O)(O)=O)=CC(S(=O)(O)=O)=CC3=C(S(=O)(O)=O)C=C2)=O)=C1)NC4=CC=CC(C(NC5=C6C(S(=O)(O)=O)=CC(S(=O)(O)=O)=CC6=C(S(=O)(O)=O)C=C5)=O)=C4.[Na].[Na].[Na].[Na].[Na].[Na]. References: F Soto, et al. Antagonistic Properties of the Suramin Analogue NF023 at Heterologously Expressed P2X Receptors. Neuropharmacology. 1999 Jan,38(1):141-9.