Mastoparan (trifluoroacetate salt)

Mastoparan is a mast cell degranulating peptide originally isolated from Vespid wasp venom. It promotes degranulation by increasing GTPase activity for Gi and Go signaling independent of G protein-coupled receptor binding. Mastoparan also binds calmodulin (Kd = 0.3 nM) and inhibits the calmodulin-induced activation of phosphodiesterase (IC50 = 0.02 µM). In vitro, mastoparan was effective in killing leukemia, myeloma, and breast cancer cells (IC50s = 8-9.2, 11, and 20-24 µM, respectively). It worked synergistically with gemcitabine in a mouse model of mammary carcinoma.Molecular Formula: C70H131N19O15 . XCF3COOH. Formula Weight: 1478.9. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml. lambdamax: 203 nm. SMILES: O=C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(N)=O)CC(C)C)=O)[C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](C)NC([C@H](CC(C)C)NC([C@H](C)NC([C@H](C)NC([C@H](CC(C)C)NC([C@H](C)NC([C@H](CCCCN)NC([C@H](CC(C)C)NC([C@H](CC(N)=O)NC([C@@H](N)[C@@H](C)CC)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.FC(F)(C(O)=O)F. InChi Code: InChI=1S/C70H131N19O15.C2HF3O2/c1-17-40(11)55(75)69(103)88-53(35-54(74)90)68(102)87-52(34-39(9)10)67(101)83-46(25-19-22-28-71)62(96)78-45(16)61(95)86-50(32-37(5)6)65(99)79-42(13)58(92)77-43(14)60(94)85-51(33-38(7)8)66(100)80-44(15)59(93)81-47(26-20-23-29-72)63(97)82-48(27-21-24-30-73)64(98)89-56(41(12)18-2)70(104)84-49(57(76)91)31-36(3)4,3-2(4,5)1(6)7/h36-53,55-56H,17-35,71-73,75H2,1-16H3,(H2,74,90)(H2,76,91)(H,77,92)(H,78,96)(H,79,99)(H,80,100)(H,81,93)(H,82,97)(H,83,101)(H,84,104)(H,85,94)(H,86,95)(H,87,102)(H,88,103)(H,89,98),(H,6,7)/t40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,55-,56-,/m0./s1. InChi Key: WZPKLDWYLMDLDU-UVXXMCETSA-N.