Lys-(Des-Arg9)-Bradykinin (trifluoroacetate salt)

Lys-(Des-Arg9)-Bradykinin is a naturally occurring peptide agonist of the bradykinin B1 receptor (Ki = 0.12 nM in HEK293 cells expressing the human receptor). It is selective for bradykinin B1 over B2 receptors (IC50 = >30,000 nM in CHO cells expressing the human receptor). Lys-(Des-Arg9)-Bradykinin increases both mRNA and protein levels of the B1 receptor in IMR-90 human lung fibroblasts in a concentration-dependent manner. It induces contraction of isolated rabbit aorta (pD2 = 8.6). Lys-(Des-Arg9)-Bradykinin decreases blood pressure in LPS-treated rabbits in a dose-dependent manner.Formal Name: 1-9-kallidin, trifluoroacetate. Synonyms: (Des-Arg10)-Kallidin, (Des-Arg10)-KD, KRPPGFSPF-OH, Lys-(Des-Arg9)-BK, N2-L-lysyl-9-de-L-arginine-Bradykinin. Molecular Formula: C50H73N13O11 . XCF3COOH. Formula Weight: 1032.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 25 mg/ml, Ethanol: 20 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: O=C(N[C@@H](CCCNC(N)=N)C(N1CCC[C@H]1C(N2CCC[C@H]2C(NCC(N[C@H](C(N[C@@H](CO)C(N3CCC[C@H]3C(N[C@H](C(O)=O)CC4=CC=CC=C4)=O)=O)=O)CC5=CC=CC=C5)=O)=O)=O)=O)[C@H](CCCCN[H])N[H].OC(C(F)(F)F)=O. InChi Code: InChI=1S/C50H73N13O11.C2HF3O2/c51-22-8-7-17-33(52)42(66)58-34(18-9-23-55-50(53)54)46(70)63-26-12-21-40(63)48(72)62-25-10-19-38(62)44(68)56-29-41(65)57-35(27-31-13-3-1-4-14-31)43(67)60-37(30-64)47(71)61-24-11-20-39(61)45(69)59-36(49(73)74)28-32-15-5-2-6-16-32,3-2(4,5)1(6)7/h1-6,13-16,33-40,64H,7-12,17-30,51-52H2,(H,56,68)(H,57,65)(H,58,66)(H,59,69)(H,60,67)(H,73,74)(H4,53,54,55),(H,6,7)/t33-,34-,35-,36-,37-,38-,39-,40-,/m0./s1. InChi Key: BUNFBEBTCVIRNN-HVJIRRSLSA-N.