[Leu5]-Enkephalin

Description: [Leu5]-Enkephalin (Leu-enkephalin) is an endogenous neuropeptide involved in nociception and an agonist of delta-opioid and µ-opioid receptors (Kis = 4.0 and 3.4 nM, respectively). Target: Endogenous Metabolite, Opioid Receptor. Smiles: CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(O)=O. References: Fabisiak A , Malgorzata Sobocinska, Elzbieta Kamysz, et al. Antinociceptive potency of enkephalins and enkephalinase inhibitors in the mouse model of colorectal distension - proof of concept[J]. Chemical Biology & Drug Design, 2018, 92(1).