L-Leucyl-L-Leucine methyl ester (hydrochloride)

L-Leucyl-L-Leucine methyl ester (LLME) is a lysosomal condensation product that has been reported to be cytotoxic towards natural killer cells and CD4+ and CD8+ T lymphocytes without affecting helper T cells and B cells. It has also been shown to induce death of monocytes, polymorphonuclear leukocytes, and myeloid tumor cells. Upon entry into cells via receptor-mediated endocytosis, LLME undergoes a condensation process catalyzed by dipeptidyl peptidase I (DPPI) in lysosomes. This condensation leads to lysosomal rupture and DNA fragmentation in DPPI-expressing immune cells such as cytotoxic T cells and natural killer cells.Formal Name: L-leucyl-L-leucine, methyl ester, monohydrochloride. CAS Number: 6491-83-4. Synonyms: LLME, LLOMe. Molecular Formula: C13H26N2O3 . HCl. Formula Weight: 294.8. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: COC([C@@H](NC([C@@H](N)CC(C)C)=O)CC(C)C)=O.Cl. InChi Code: InChI=1S/C13H26N2O3.ClH/c1-8(2)6-10(14)12(16)15-11(7-9(3)4)13(17)18-5,/h8-11H,6-7,14H2,1-5H3,(H,15,16),1H/t10-,11-,/m0./s1. InChi Key: RVXQFTNCULOWRV-ACMTZBLWSA-N.