L-Alanyl-L-Glutamine

L-Alanyl-L-glutamine is a synthetic glutamine dipeptide that can attenuate oxidative stress in rodent models when administered at doses of 0.75-1.5 mg/kg. In vivo, the parenteral administration of L-alanyl-L-glutamine to Swiss mice yields higher plasma glutamine levels compared to enteral administration. In vitro, the addition of this dipeptide (50 mM) to cultures of antibody-producing CHO cells reduces apoptosis and promotes antibody production. Treatment of insulin-secreting BRIN-BD11 beta-cells with L-alanyl-L-glutamine (2 mM) protects against the inflammatory effects of exposure to lipopolysaccharide-treated primary macrophages.Formal Name: L-alanyl-L-glutamine. CAS Number: 39537-23-0. Synonyms: Ala-Gln, L-Ala-L-Gln. Molecular Formula: C8H15N3O4. Formula Weight: 217.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 20 mg/ml, PBS (pH 7.2): 2 mg/ml. lambdamax: 204 nm. SMILES: NC(CC[C@H](NC([C@H](C)N)=O)C(O)=O)=O. InChi Code: InChI=1S/C8H15N3O4/c1-4(9)7(13)11-5(8(14)15)2-3-6(10)12/h4-5H,2-3,9H2,1H3,(H2,10,12)(H,11,13)(H,14,15)/t4-,5-/m0/s1. InChi Key: HJCMDXDYPOUFDY-WHFBIAKZSA-N.