HS-024 (trifluoroacetate salt)

HS-024 is a cyclic peptide antagonist of melanocortin receptor 4 (MC4R, Ki = 0.29 nM). It is selective for MC4R over MC1R, MC3R, and MC5R (Kis = 18.6, 5.45, and 3.29 nM, respectively). HS-024 (100 nM) inhibits cAMP accumulation induced by alpha-melanocyte-stimulating hormone (alpha-MSH, Cay-29923) in COS-1 cells expressing human MC1R, MC3R, MC4R, or MC5R. It increases food intake in rats when administered at doses of 0.3, 1, or 3 nmol/animal. Intrathecal administration of HS-024 (1.5 nmol/animal) inhibits mechanical allodynia at 30 minutes post-injection in a rat model of spinal nerve ligation-induced neuropathic pain. It reduces stress-induced reinstatement of nicotine seeking in the foot shock test in rats.Formal Name: cyclic (1->9)-disulfide, N-acetyl-L-cysteinyl-L-norleucyl-L-arginyl-L-histidyl-3-(2-naphthalenyl)-D-alanyl-L-tryptophylglycyl-L-cysteinamide, trifluoroacetate salt. Synonyms: Ac-Cys-Nle-Arg-His-D-Nal-Arg-Trp-Gly-Cys-NH2, cyclic [AcCys3,Nle4,Arg5,D-Nal7,Cys-NH211]alpha-MSH-(3-11). Molecular Formula: C58H79N19O10S2 . XCF3COOH. Formula Weight: 1266.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble: >10 mg/m, Ethanol: Soluble: >10 mg/ml, PBS (pH 7.2): Soluble: >10 mg/ml. SMILES: O=C([C@@H](NC([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CSSC[C@H](NC(CNC1=O)=O)C(N)=O)NC(C)=O)=O)CCCC)=O)CCCNC(N)=N)=O)CC2=CN=CN2)=O)CC3=CC4=C(C=CC=C4)C=C3)=O)CCCNC(N)=N)N[C@H]1CC5=CNC6=CC=CC=C56.O=C(O)C(F)(F)F. InChi Code: InChI=1S/C58H79N19O10S2.C2HF3O2/c1-3-4-14-40-51(82)72-41(16-9-20-65-57(60)61)53(84)77-45(25-37-27-64-31-69-37)55(86)75-43(23-33-18-19-34-11-5-6-12-35(34)22-33)54(85)73-42(17-10-21-66-58(62)63)52(83)76-44(24-36-26-67-39-15-8-7-13-38(36)39)50(81)68-28-48(79)71-46(49(59)80)29-88-89-30-47(56(87)74-40)70-32(2)78,3-2(4,5)1(6)7/h5-8,11-13,15,18-19,22,26-27,31,40-47,67H,3-4,9-10,14,16-17,20-21,23-25,28-30H2,1-2H3,(H2,59,80)(H,64,69)(H,68,81)(H,70,78)(H,71,79)(H,72,82)(H,73,85)(H,74,87)(H,75,86)(H,76,83)(H,77,84)(H4,60,61,65)(H4,62,63,66),(H,6,7)/t40-,41-,42-,43+,44-,45-,46-,47-,/m0./s1. InChi Key: KFPPOAMKLLTSNH-KMPRNXRMSA-N.