hMC1R Agonist 1 (acetate)

hMC1R agonist 1 is a peptide agonist of melanocortin receptor 1 (MC1R) and a derivative of melanotan-II (Cay-27316). It selectively induces cAMP production in HEK293 cells expressing recombinant human MC1R over those expressing recombinant human MC3R, MC4R, or MC5R (EC50s = 3, 902, 915, and >1,000 nM, respectively).Formal Name: (5R,8S,11S,14R,17S,20R)-17-((1H-imidazol-5-yl)methyl)-8-((1H-indol-3-yl)methyl)-20-((S)-2-acetamidohexanamido)-14-benzyl-11-(3-guanidinopropyl)-7,10,13,16,19-pentaoxo-3,22-dithia-6,9,12,15,18-pentaaza-1(1,3)-benzenacyclotricosaphane-5-carboxamide, acetate. Synonyms: Ac-Nle-[CHfRWC]-NH2, Ac-Nle-[Cys-His-D-Phe-Arg-Trp-Cys]-NH2. Molecular Formula: C54H70N14O8S2 . XC2H4O2. Formula Weight: 1107.4. Purity: >98%. Formulation: (Request formulation change), A solid. Peptide Sequence: Ac-XCHfRWC-NH2 (X=Norleucine). Solubility: DMSO: Soluble: >10 mg/mL, Ethanol: Soluble: >10 mg/mL. SMILES: O=C(N[C@@H](CSCC1=CC(CSC[C@@H](C(N[C@H](C(N[C@@H](C(N[C@H]2CCCNC(N)=N)=O)CC3=CC=CC=C3)=O)CC4=CN=CN4)=O)NC([C@H](CCCC)NC(C)=O)=O)=CC=C1)C(N)=O)[C@H](CC5=CNC6=CC=CC=C65)NC2=O.CC(O)=O. InChi Code: InChI=1S/C54H70N14O8S2.C2H4O2/c1-3-4-17-40(62-32(2)69)48(71)68-46-30-78-28-35-15-10-14-34(21-35)27-77-29-45(47(55)70)67-51(74)43(23-36-25-60-39-18-9-8-16-38(36)39)65-49(72)41(19-11-20-59-54(56)57)63-50(73)42(22-33-12-6-5-7-13-33)64-52(75)44(66-53(46)76)24-37-26-58-31-61-37,1-2(3)4/h5-10,12-16,18,21,25-26,31,40-46,60H,3-4,11,17,19-20,22-24,27-30H2,1-2H3,(H2,55,70)(H,58,61)(H,62,69)(H,63,73)(H,64,75)(H,65,72)(H,66,76)(H,67,74)(H,68,71)(H4,56,57,59),1H3,(H,3,4)/t40-,41-,42+,43-,44-,45-,46-,/m0./s1. InChi Key: OLKDAILISXTDEX-ICQWWELKSA-N.