Histone H3K79Me3 (73-83) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)

Histone H3K79Me3 (73-83) is a peptide fragment of histone H3 that corresponds to amino acid residues 74-84 of the human histone H3 sequence. Trimethylation of histone H3 at lysine 79 is found at promoter regions of both active and silenced genes in human CD4+ T cells and positively correlates with transcriptional repression. H3K79 trimethylation is also found at pericentromeric heterochromatin in mouse oocytes and somatic cells. Levels of H3K79Me3 are decreased in human tumor tissue compared to non-cancerous tissue.Formal Name: L-alpha-glutamyl-L-isoleucyl-L-alanyl-L-glutaminyl-L-alpha-aspartyl-L-phenylalanyl-6-(trimethylammonio)-L-norleucyl-L-threonyl-L-alpha-aspartyl-L-leucyl-L-arginine, trifluoroacetate salt. Synonyms: EIAQDF-K(Me3)-TDLR, H3K79me3, Histone H3 (73-83) (Lys79me3), H-Glu-Ile-Ala-Gln-Asp-Phe-Lys(Me3)-Thr-Asp-Leu-Arg-OH, [Lys(Me3)79]-Histone H3 (73-83). Molecular Formula: C61H101N16O20 . XCF3COO. Formula Weight: 1378.6. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Water: 1 mg/ml. SMILES: O=C([O-])C(F)(F)F.C[N+](C)(C)CCCC[C@H](NC([C@H](CC1=CC=CC=C1)NC([C@H](CC(O)=O)NC([C@@H](NC([C@H](C)NC([C@@]([H])(NC([C@@H](N)CCC(O)=O)=O)[C@@H](C)CC)=O)=O)CCC(N)=O)=O)=O)=O)C(N[C@]([H])(C(N[C@@H](CC(O)=O)C(N[C@H](C(N[C@H](C(O)=O)CCCNC(N)=N)=O)CC(C)C)=O)=O)[C@H](O)C)=O. InChi Code: InChI=1S/C61H100N16O20.C2HF3O2/c1-10-32(4)48(75-51(87)36(62)21-24-45(80)81)58(94)67-33(5)50(86)68-38(22-23-44(63)79)52(88)73-42(29-46(82)83)56(92)72-41(28-35-17-12-11-13-18-35)55(91)69-37(19-14-15-26-77(7,8)9)53(89)76-49(34(6)78)59(95)74-43(30-47(84)85)57(93)71-40(27-31(2)3)54(90)70-39(60(96)97)20-16-25-66-61(64)65,3-2(4,5)1(6)7/h11-13,17-18,31-34,36-43,48-49,78H,10,14-16,19-30,62H2,1-9H3,(H19-,63,64,65,66,67,68,69,70,71,72,73,74,75,76,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97),(H,6,7)/t32-,33-,34+,36-,37-,38-,39-,40-,41-,42-,43-,48-,49-,/m0./s1. InChi Key: IJYRWOIKCWJYNU-ZCRTVYFESA-N.