Histone H3K4Me3 (1-25) amide (human mouse, rat, porcine, bovine) (trifluoroacetate salt)

Histone H3K4Me3 (1-25) amide is an N-terminal peptide fragment of histone H3 that corresponds to amino acid residues 2-26 of the human histone H3 sequence. Trimethylation of histone H3 at lysine 4 is found in euchromatic promoter regions and is associated with active transcription. It inhibits several H3K9 methyltransferases and has differential effects on the activities of the KDM7 demethylases PHF8 and KDM7A, activating and inhibiting H3K9Me3 demethylation, respectively. Mislocalization of H3K4Me3 is associated with disease progression and memory deficits in patients with Alzheimer's disease.Formal Name: L-alanyl-L-arginyl-L-threonyl-6-(trimethylammonio)-L-norleucyl-L-glutaminyl-L-threonyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-threonylglycylglycyl-L-lysyl-L-alanyl-L-prolyl-L-arginyl-L-lysyl-L-glutaminyl-L-leucyl-L-alanyl-L-threonyl-L-lysyl-L-alanyl-L-alaninamide, trifluoroacetate salt. Synonyms: ART-K(Me3)-QTARKSTGGKAPRKQLATKAA-NH2, Histone H3 (1-25) (Lys4me3), H3K4me3, [Lys(Me3)4]-Histone H3 (1-25) amide. Molecular Formula: C113H209N42O32 . XCF3COO. Formula Weight: 2668.1. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Water: 1 mg/ml. SMILES: O=C([O-])C(F)(F)F.NC([C@H](C)NC([C@H](C)NC([C@@H](NC([C@@]([H])(NC([C@H](C)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H]1CCCN1C([C@H](C)NC([C@@H](NC(CNC(CNC([C@@]([H])(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](C)NC([C@@]([H])(NC([C@@H](NC([C@@H](NC([C@@]([H])(NC([C@@H](NC([C@H](C)N)=O)CCCNC(N)=N)=O)[C@H](O)C)=O)CCCC[N+](C)(C)C)=O)CCC(N)=O)=O)[C@H](O)C)=O)=O)CCCNC(N)=N)=O)CCCCN)=O)CO)=O)[C@H](O)C)=O)=O)=O)CCCCN)=O)=O)=O)CCCNC(N)=N)=O)CCCCN)=O)CCC(N)=O)=O)CC(C)C)=O)=O)[C@H](O)C)=O)CCCCN)=O)=O)=O. InChi Code: InChI=1S/C113H208N42O32.C2HF3O2/c1-56(2)52-77(103(180)135-61(7)92(169)150-86(65(11)159)108(185)146-68(31-17-22-44-115)94(171)134-59(5)90(167)133-58(4)88(121)165)148-100(177)75(39-41-80(119)161)143-95(172)69(32-18-23-45-116)141-98(175)73(36-27-48-129-112(124)125)145-105(182)79-38-29-50-154(79)110(187)62(8)137-93(170)67(30-16-21-43-114)138-83(164)54-131-82(163)53-132-106(183)84(63(9)157)151-104(181)78(55-156)149-99(176)70(33-19-24-46-117)142-97(174)72(35-26-47-128-111(122)123)140-91(168)60(6)136-107(184)85(64(10)158)152-102(179)76(40-42-81(120)162)144-96(173)71(34-20-25-51-155(13,14)15)147-109(186)87(66(12)160)153-101(178)74(139-89(166)57(3)118)37-28-49-130-113(126)127,3-2(4,5)1(6)7/h56-79,84-87,156-160H,16-55,114-118H2,1-15H3,(H40-,119,120,121,122,123,124,125,126,127,128,129,130,131,132,133,134,135,136,137,138,139,140,141,142,143,144,145,146,147,148,149,150,151,152,153,161,162,163,164,165,166,167,168,169,170,171,172,173,174,175,176,177,178,179,180,181,182,183,184,185,186),(H,6,7)/t57-,58-,59-,60-,61-,62-,63+,64+,65+,66+,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,84-,85-,86-,87-,/m0./s1. InChi Key: SXLNNWJFGBGNNJ-KYAVQZSNSA-N.