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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay27765-250 | 250 µg | - |
6 - 10 business days* |
319.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Histone H3K27Me1 (21-44)-GK-biotin is a peptide fragment of histone H3 that corresponds to amino... more
Product information "Histone H3K27Me1 (21-44)-GK-biotin (trifluoroacetate salt)"
Histone H3K27Me1 (21-44)-GK-biotin is a peptide fragment of histone H3 that corresponds to amino acid residues 22-45 of the human histone H3.1 and H3.2 sequences. It is monomethylated at lysine 27 and biotinylated via a C-terminal GK linker. Monomethylation of histone H3 at lysine 27 is associated with actively transcribed genes and positively correlates with H3K36 trimethylation. Levels of H3K27Me1 are increased in tumor tissue isolated from patients with metastatic hormone-naïve and castration-resistant prostate cancer. Histone H3K27Me1 (21-44)-GK-biotin has been used in a high-throughput screen for inhibitors of the histone demethylase jumonji AT-rich interactive domain 1B (JARID1B).Formal Name: L-alanyl-L-threonyl-L-lysyl-L-alanyl-L-alanyl-L-arginyl-N6-methyl-L-lysyl-L-seryl-L-alanyl-L-prolyl-L-alanyl-L-threonylglycylglycyl-L-valyl-L-lysyl-L-lysyl-L-prolyl-L-histidyl-L-arginyl-L-tyrosyl-L-arginyl-L-proylglycylglycyl-L-lysinate-biotin, trifluoroacetate salt. Synonyms: ATKAAR-K(Me1)-SAPATGGVKKPHRYRPG-GK(Biotin), [Lys(Me1)27]-Histone H3 (21-44)-GK(Biotin), Histone H3 (21-44) (Lys27me1). Molecular Formula: C128H216N44O33S . XCF3COOH. Formula Weight: 2931.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Water: 1 mg/ml. SMILES: O=C(O)C(F)(F)F.O=C(NCCCC[C@@H](C(O)=O)NC(CNC(CNC([C@@H]1CCCN1C([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@@H]2CCCN2C([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](C(C)C)NC(CNC(CNC([C@@]([C@@H](C)O)([H])NC([C@@H](NC([C@@H]3CCCN3C([C@@H](NC([C@H](CO)NC([C@H](CCCCNC)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@@H](NC([C@H](CCCCN)NC([C@@]([C@@H](C)O)([H])NC([C@@H](N[H])C)=O)=O)=O)C)=O)C)=O)=O)=O)=O)C)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)CC4=CN=CN4)=O)=O)CC5=CC=C(O)C=C5)=O)=O)=O)=O)=O)CCCC[C@@H]6SC[C@@](N7)([H])[C@]6([H])NC7=O. InChi Code: InChI=1S/C128H216N44O33S.C2HF3O2/c1-67(2)99(166-98(181)63-146-96(179)61-148-118(197)100(73(8)174)168-106(185)71(6)152-116(195)91-38-27-54-170(91)121(200)72(7)153-114(193)88(64-173)164-111(190)79(31-16-21-49-139-10)156-108(187)81(34-23-51-142-125(133)134)155-105(184)70(5)150-104(183)69(4)151-107(186)78(29-13-18-46-129)159-120(199)101(74(9)175)167-103(182)68(3)132)119(198)158-80(30-14-19-47-130)109(188)160-83(32-15-20-48-131)122(201)172-56-28-39-92(172)117(196)163-87(58-76-59-140-66-149-76)113(192)157-82(35-24-52-143-126(135)136)110(189)162-86(57-75-42-44-77(176)45-43-75)112(191)161-84(36-25-53-144-127(137)138)123(202)171-55-26-37-90(171)115(194)147-60-95(178)145-62-97(180)154-85(124(203)204)33-17-22-50-141-94(177)41-12-11-40-93-102-89(65-206-93)165-128(205)169-102,3-2(4,5)1(6)7/h42-45,59,66-74,78-93,99-102,139,173-176H,11-41,46-58,60-65,129-132H2,1-10H3,(H,140,149)(H,141,177)(H,145,178)(H,146,179)(H,147,194)(H,148,197)(H,150,183)(H,151,186)(H,152,195)(H,153,193)(H,154,180)(H,155,184)(H,156,187)(H,157,192)(H,158,198)(H,159,199)(H,160,188)(H,161,191)(H,162,189)(H,163,196)(H,164,190)(H,166,181)(H,167,182)(H,168,185)(H,203,204)(H4,133,134,142)(H4,135,136,143)(H4,137,138,144)(H2,165,169,205),(H,6,7)/t68-,69-,70-,71-,72-,73+,74+,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,99-,100-,101-,102-,/m0./s1. InChi Key: OGXVJMUALYKZHC-GHMNIEHUSA-N.
Keywords: | [Lys(Me1)27]-Histone H3 (21-44)-GK(Biotin), ATKAAR-K(Me1)-SAPATGGVKKPHRYRPG-GK(Biotin), Histone H3 (21-44) (Lys27me1), L-alanyl-L-threonyl-L-lysyl-L-alanyl-L-alanyl-L-arginyl-N6-methyl-L-lysyl-L-seryl-L-alanyl-L-prolyl-L-alanyl-L-threonylglycylglycyl-L-va |
Supplier: | Cayman Chemical |
Supplier-Nr: | 27765 |
Properties
Application: | Biotinylated histone H3 peptide fragment |
Conjugate: | No |
MW: | 2931.5 D |
Formula: | C128H216N44O33S . XCF3COOH |
Purity: | >95% |
Format: | Solid |
Database Information
KEGG ID : | K11253 | Matching products |
UniProt ID : | P68431 | Matching products |
Gene ID | GeneID 8350 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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