GHK-Cu (acetate)

GHK-Cu is a complex of the tripeptide Gly-His-Lys and a copper(II) ion that has wound healing and anti-inflammatory activities. It increases proliferation and the levels of collagen and secreted pro-matrix metalloproteinase-2 (MMP-2) in isolated human fibroblasts when used at a concentration of 1 nM. GHK-Cu (2 mg) increases levels of collagen and glycosaminoglycans (GAGs) and the expression of decorin in the wound tissue of rats. It decreases LPS-induced increases in the levels of reactive oxygen species (ROS), IL-6, and TNF-alpha in RAW 264.7 cells when used at a concentration of 10 µM. GHK-Cu (10 µg/g) prevents LPS-induced decreases in lung superoxide dismutase (SOD) activity and glutathione (GSH) levels and reduces LPS-induced increases in the number of cells and the level of total protein in bronchoalveolar lavage fluid (BALF) in a mouse model of acute lung injury.Formal Name: [glycyl-kappaN-L-histidyl-kappaN,kappaN3-L-lysinato(2-)]-copper, monoacetate. CAS Number: 300801-03-0. Synonyms: Gly-His-Lys-Cu(II). Molecular Formula: C14H22CuN6O4 . C2H4O2. Formula Weight: 462.0. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: PBS (pH 7.2): 5 mg/ml. SMILES: CC(O)=O.O=C([C@H]1[N-](C2=O)[Cu+2]([NH2]C2)[N]3=CNC=C3C1)N[C@H](C([O-])=O)CCCCN. InChi Code: InChI=1S/C14H24N6O4.C2H4O2.Cu/c15-4-2-1-3-10(14(23)24)20-13(22)11(19-12(21)6-16)5-9-7-17-8-18-9,1-2(3)4,/h7-8,10-11H,1-6,15-16H2,(H4,17,18,19,20,21,22,23,24),1H3,(H,3,4),/q,,+2/p-2/t10-,11-,,/m0../s1. InChi Key: NOIHSRSQDMJJFH-ULEGLUPFSA-L.