Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
FSL-1 is a synthetic lipopeptide agonist of toll-like receptor 2 (TLR2) and TLR6 heterodimers... more
Product information "FSL-1 (trifluoroacetate salt)"
FSL-1 is a synthetic lipopeptide agonist of toll-like receptor 2 (TLR2) and TLR6 heterodimers (TLR2/TLR6). In HEK293 cells transfected with human TLR2 and TLR6 but not TLR6 alone, FSL-1 increases NF-kappaB activity by 4- and 8-fold when used at concentrations of 0.1 and 1 nM, respectively. It induces the expression of the cytokines CCL20, IL-8, IL-1beta, and TNF-alpha in human monocytic THP-1 cells and, to a lesser extent, in TLR10 knockdown cells when used at a concentration of 100 ng/ml. FSL-1 (0.5-50 µg/ml), in combination with IFN-gamma, dose-dependently increases the percentage of DM13 and VMM1 melanoma cells expressing the chemokine CXCL10 with a maximal increase of approximately 50%. In rats, FSL-1 (100 µg/kg, i.p.) induces fever and increases plasma levels of IL-6 and TNF-alpha by greater than 90-fold. FSL-1 (10-1,000 µg/kg, i.p.) also dose-dependently reduces home cage locomotor activity and both food and water consumption with maximal reductions of ten grams per 12 hours.Formal Name: S-[2,3-bis[(1-oxohexadecyl)oxy]propyl]-L-cysteinylglycyl-L-alpha-aspartyl-L-prolyl-L-lysyl-L-histidyl-L-prolyl-L-lysyl-L-seryl-L-phenylalanine, trifluoroacetate salt. Molecular Formula: C84H140N14O18S . XCF3COOH. Formula Weight: 1666.2. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Water: 2 mg/ml. SMILES: O=C(O)[C@@H](NC([C@H](CO)NC([C@H](CCCCN)NC([C@H]1N(C([C@@H](NC([C@H](CCCCN)NC([C@@H]2CCCN2C([C@H](CC(O)=O)NC(CNC([C@@H](N)CSCC(OC(CCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O)=O)=O)=O)=O)=O)CC3=CN=CN3)=O)CCC1)=O)=O)=O)CC4=CC=CC=C4.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C84H140N14O18S.C2HF3O2/c1-3-5-7-9-11-13-15-17-19-21-23-25-30-44-74(103)115-56-62(116-75(104)45-31-26-24-22-20-18-16-14-12-10-8-6-4-2)57-117-58-63(87)76(105)89-54-72(100)91-67(52-73(101)102)83(112)98-49-37-43-71(98)81(110)92-64(40-32-34-46-85)77(106)94-66(51-61-53-88-59-90-61)82(111)97-48-36-42-70(97)80(109)93-65(41-33-35-47-86)78(107)96-69(55-99)79(108)95-68(84(113)114)50-60-38-28-27-29-39-60,3-2(4,5)1(6)7/h27-29,38-39,53,59,62-71,99H,3-26,30-37,40-52,54-58,85-87H2,1-2H3,(H,88,90)(H,89,105)(H,91,100)(H,92,110)(H,93,109)(H,94,106)(H,95,108)(H,96,107)(H,101,102)(H,113,114),(H,6,7)/t62?,63-,64-,65-,66-,67-,68-,69-,70-,71-,/m0./s1. InChi Key: UANJOAKJMWZEBV-ALAVPRNSSA-N.
Keywords: | S-[2,3-bis[(1-oxohexadecyl)oxy]propyl]-L-cysteinylglycyl-L-alpha-aspartyl-L-prolyl-L-lysyl-L-histidyl-L-prolyl-L-lysyl-L-seryl-L-phenylalanine, trifluoroacetate salt |
Supplier: | Cayman Chemical |
Supplier-Nr: | 24220 |
Properties
Application: | TLR2/TLR6 agonist |
Conjugate: | No |
MW: | 1666.2 D |
Formula: | C84H140N14O18S . XCF3COOH |
Purity: | >95% |
Format: | Solid |
Database Information
KEGG ID : | K10169 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
more
You will get a certificate here
Viewed