DADLE

DADLE is a peptide agonist of delta-opioid receptors (Ki = 2.06 nM in a radioligand binding assay). It is selective for delta-opioid over kappa-opioid receptors (Ki = 16,000 nM) but also agonizes µ-opioid receptors (Ki = 13.8 nM). DADLE inhibits electrically induced contractions in guinea pig myenteric plexus and mouse and rat vas deferens (IC50s = 8.9, 0.73, and 134 nM, respectively). It induces analgesia in the tail-flick and hot plate tests in mice (ED50s = 0.03 and 0.027 nmol per animal, i.c.v.).Formal Name: L-tyrosyl-D-alanylglycyl-L-phenylalanyl-D-leucine. CAS Number: 63631-40-3. Synonyms: [D-Ala2, D-Leu5]-Enkephalin. Molecular Formula: C29H39N5O7. Formula Weight: 569.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 25 mg/ml, Ethanol: 3 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: OC1=CC=C(C[C@H](N)C(N[C@H](C)C(NCC(N[C@@H](CC2=CC=CC=C2)C(N[C@H](CC(C)C)C(O)=O)=O)=O)=O)=O)C=C1. InChi Code: InChI=1S/C29H39N5O7/c1-17(2)13-24(29(40)41)34-28(39)23(15-19-7-5-4-6-8-19)33-25(36)16-31-26(37)18(3)32-27(38)22(30)14-20-9-11-21(35)12-10-20/h4-12,17-18,22-24,35H,13-16,30H2,1-3H3,(H,31,37)(H,32,38)(H,33,36)(H,34,39)(H,40,41)/t18-,22+,23+,24-/m1/s1. InChi Key: ZHUJMSMQIPIPTF-IBURTVSXSA-N.