Cyclo(Delta-Ala-L-Val)

Cyclo(Delta-Ala-L-Val) is a bacterial cyclic dipeptide characterized as a diketopiperazine. It activates a LuxR-based N-acylhomoserine lactone (AHL) E. coli biosensor and blocks activation of the biosensor by the quorum sensing signal molecule N-(beta-ketocaproyl)-L-homoserine lactone (3-oxo-C6-HSL, Cay-10011207) with an IC50 value of 0.8 mM. Cyclo(Delta-Ala-L-Val) (15 µM) reduces S. liquefaciens colony expansion by 21%, indicating inhibition of swarming motility. It also inhibits the interaction of the kinases Ras and Raf-1 in a yeast two-hybrid assay in a concentration-dependent manner.Formal Name: 3-methylene-6S-(1-methylethyl)-2,5-piperazinedione. CAS Number: 25516-00-1. Molecular Formula: C8H12N2O2. Formula Weight: 168.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: soluble, DMSO: soluble, Ethanol: soluble, Methanol: soluble. SMILES: O=C(C(N1)=C)N[C@@H](C(C)C)C1=O. InChi Code: InChI=1S/C8H12N2O2/c1-4(2)6-8(12)9-5(3)7(11)10-6/h4,6H,3H2,1-2H3,(H,9,12)(H,10,11)/t6-/m0/s1. InChi Key: NFYRGJUKSGFWQF-LURJTMIESA-N.