Caloxin 2A1 (trifluoroacetate salt)

Caloxin 2A1 is a peptide plasma membrane Ca2+/Mg2+-ATPase inhibitor (IC50 = 0.4 mM in erythrocyte leaky ghosts). It is selective for the plasma membrane Ca2+/Mg2+-ATPase over the erythrocyte ghost Mg2+- and Na+/K+-ATPases and the skeletal muscle sarcoplasmic reticulum Ca2+/Mg2+-ATPase at 0.9 mM. Caloxin 2A1 (0.34 mM) induces relaxation in precontracted rat aortic rings, an effect that can be reversed by the nitric oxide synthase inhibitor L-NAME (Cay-80210).Formal Name: L-valyl-L-seryl-L-asparaginyl-L-seryl-L-asparaginyl-L-tryptophyl-L-prolyl-L-seryl-L-phenylalanyl-L-prolyl-L-seryl-L-serylglycylglycyl-glycinamide, trifluoroacetate salt. Synonyms: VSNSNWPSFPSSGGG-NH2. Molecular Formula: C64H91N19O22 . XCF3COOH. Formula Weight: 1478.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Water: 1 mg/ml. SMILES: O=C(N1[C@H](C(N[C@@H](CO)C(N[C@@H](CC2=CC=CC=C2)C(N3CCC[C@H]3C(N[C@@H](CO)C(N[C@@H](CO)C(NCC(NCC(NCC(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)CCC1)[C@@H](NC([C@H](CC(N)=O)NC([C@H](CO)NC([C@H](CC(N)=O)NC([C@H](CO)NC([C@@H](N)C(C)C)=O)=O)=O)=O)=O)CC4=CNC5=CC=CC=C45.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C64H91N19O22/c1-31(2)52(68)62(103)81-44(30-88)57(98)74-37(21-48(66)90)55(96)78-41(27-85)56(97)73-36(20-47(65)89)54(95)76-39(19-33-22-69-35-13-7-6-12-34(33)35)64(105)83-17-9-15-46(83)61(102)79-42(28-86)58(99)75-38(18-32-10-4-3-5-11-32)63(104)82-16-8-14-45(82)60(101)80-43(29-87)59(100)77-40(26-84)53(94)72-25-51(93)71-24-50(92)70-23-49(67)91/h3-7,10-13,22,31,36-46,52,69,84-88H,8-9,14-21,23-30,68H2,1-2H3,(H2,65,89)(H2,66,90)(H2,67,91)(H,70,92)(H,71,93)(H,72,94)(H,73,97)(H,74,98)(H,75,99)(H,76,95)(H,77,100)(H,78,96)(H,79,102)(H,80,101)(H,81,103)/t36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,52-/m0/s1. InChi Key: WWVYZHSQQMQNOR-HPUWVREWSA-N.