Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used
![Apamin (trifluoroacetate salt)](https://www.biomol.com/media/image/cb/87/67/Cay17082-500_600x600.png)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay17082-500 | 500 µg | - |
6 - 10 business days* |
214.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Apamin is an 18-amino acid peptide toxin that has been found in honey bee (A. mellifera) venom.... more
Product information "Apamin (trifluoroacetate salt)"
Apamin is an 18-amino acid peptide toxin that has been found in honey bee (A. mellifera) venom. It is an inhibitor of small conductance calcium-activated potassium (KCa2.2/SK2) channels (IC50s = 0.06-0.4 nM). It is selective for KCa2.2/SK2 channels over KCa2.1/SK1 and KCa2.3/SK3 channels (IC50s = 1-12 and 1-13 nM, respectively), as well as the intermediate-conductance calcium-activated potassium channel KCa3.1/SK4 at 1 µM but does inhibit voltage-gated potassium channel 1.3 (Kv1.3, IC50 = 13 nM). Apamin (50 µg/kg) reduces CD8+ cell infiltration into the CNS and the severity of experimental autoimmune encephalomyelitis (EAE), as well as increased peripheral blood levels of CD62L-, CD44L-, and CD44+ memory T cells in mice. It has commonly been used to determine the role of KCa/SK channels in the brain, vascular endothelium, and bladder.Formal Name: L-cysteinyl-L-asparaginyl-L-cysteinyl-L-lysyl-L-alanyl-L-prolyl-L-alpha-glutamyl-L-threonyl-L-alanyl-L-leucyl-L-cysteinyl-L-alanyl-L-arginyl-L-arginyl-L-cysteinyl-L-glutaminyl-L-glutaminyl-L-histidinamide, cyclic (1->11),(3->15)-bis(disulfide), trifluoroacetate salt. CAS Number: 24345-16-2. Synonyms: Ro 23-6721. Molecular Formula: C79H131N31O24S4 . XCF3COOH. Formula Weight: 2027.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Water: 1 mg/ml. SMILES: O=C([C@]1(N(CCC1)C([C@H](C)NC([C@H](CCCCN)NC([C@@]([H])(NC([C@@H](CC(N)=O)NC([C@@](N)([H])CSSC2)=O)=O)CSSC[C@@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC3=CNC=N3)C(N)=O)=O)CCC(N)=O)=O)CCC(N)=O)=O)NC([C@H](CCCNC(N)=N)NC4=O)=O)=O)=O)=O)[H])N[C@@H](CCC(O)=O)C(N[C@@H]([C@@H](C)O)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@]2(C(N[C@@H](C)C(N[C@]4(CCCNC(N)=N)[H])=O)=O)[H])=O)=O)=O)=O.FC(F)(C(O)=O)F. InChi Code: InChI=1S/C79H131N31O24S4.C2HF3O2/c1-35(2)26-49-70(127)107-51-31-136-135-30-41(81)63(120)105-50(28-57(84)114)71(128)108-53(73(130)99-42(12-7-8-22-80)64(121)96-38(5)77(134)110-25-11-15-54(110)75(132)102-47(18-21-58(115)116)69(126)109-59(39(6)111)76(133)95-37(4)62(119)104-49)33-138-137-32-52(106-66(123)44(14-10-24-92-79(88)89)98-65(122)43(13-9-23-91-78(86)87)97-61(118)36(3)94-72(51)129)74(131)101-45(16-19-55(82)112)67(124)100-46(17-20-56(83)113)68(125)103-48(60(85)117)27-40-29-90-34-93-40,3-2(4,5)1(6)7/h29,34-39,41-54,59,111H,7-28,30-33,80-81H2,1-6H3,(H2,82,112)(H2,83,113)(H2,84,114)(H2,85,117)(H,90,93)(H,94,129)(H,95,133)(H,96,121)(H,97,118)(H,98,122)(H,99,130)(H,100,124)(H,101,131)(H,102,132)(H,103,125)(H,104,119)(H,105,120)(H,106,123)(H,107,127)(H,108,128)(H,109,126)(H,115,116)(H4,86,87,91)(H4,88,89,92),(H,6,7)/t36-,37-,38-,39+,41+,42-,43-,44-,45-,46-,47-,48-,49-,50+,51+,52-,53-,54-,59-,/m0./s1. InChi Key: GUBJIBRYPCCYMV-ZKPRYNSTSA-N.
Keywords: | Ro 23-6721, L-cysteinyl-L-asparaginyl-L-cysteinyl-L-lysyl-L-alanyl-L-prolyl-L-alpha-glutamyl-L-threonyl-L-alanyl-L-leucyl-L-cysteinyl-L-alanyl-L-arginyl-L-arginyl-L-cysteinyl-L-glutaminyl-L-glutaminyl-L-histidinamide, cyclic (1->11),(3->15)-bis(disulfide) |
Supplier: | Cayman Chemical |
Supplier-Nr: | 17082 |
Properties
Application: | Bee venom toxin, KCa2 blocker |
Conjugate: | No |
MW: | 2027.3 D |
Formula: | C79H131N31O24S4 . XCF3COOH |
Purity: | >95% |
Format: | Solid |
Database Information
CAS : | 24345-16-2| Matching products |
KEGG ID : | K04943 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
more
You will get a certificate here
Viewed