Other Peptides

3,3',5'-Triiodo-L-thyronine, also known as reverse T3 (rT3), is a thyroid hormone generated by deiodination of the prohormone thyroxine. It is about 1,000-fold less active at the thyroid hormone receptors TRalpha and TRbeta than 3,3',5-triiodo-L-thyronine (Cay-16028) and commonly described as inactive. However, high...

Angiotensin II is a peptide hormone known best as a vasoconstrictor with central roles in chronic hypertension, heart failure, and stroke. It is an octapeptide typically generated by the removal of two residues from angiotensin I by angiotensin-converting enzyme (ACE). Angiotensin II is a ligand for at least two...

Tentoxin is a cyclic tetrapeptide first isolated from the plant pathogen A. alternata. It is an herbicide that inhibits chloroplast development, resulting in chlorotic tissue. Tentoxin is selectively phytotoxic, as it kills a number of important weeds at concentrations that have no effects on several important...

Glucagon is a peptide hormone produced from proglucagon in pancreatic alpha cells that has a role in the regulation of glucose metabolism. Pulsatile application of glucagon to rat hepatocytes stimulates glucose production ex vivo. It also stimulates glucose output from perfused rat livers via increases in...

Description: Carnostatine (SAN9812) is a potent and selective carnosinase 1 (CN1) inhibitor with a K_i of 11 nM for human recombinant CN1. It may be used to increase renal carnosine concentration as a potential therapeutic modality for diabetic nephropathy (DN). [1]. Target: Others. Smiles:...

Description: Carnostatine hydrochloride (SAN9812 hydrochloride) is a potent and selective inhibitor of carnosinase 1 (CN1), with a K_i of 11 nM against human recombinant CN1, showing promise for the treatment of diabetic nephropathy (DN) [1]. Target: Others. Smiles: OC([C@@H](NC([C@@H](O)CCN)=O)CC1=CNC=N1)=O.Cl....

Description: Lysipressin acetate(50-57-7(fb_acetate)) ([Lys8]-Vasopressin acetate) , Induces contraction of the rabbit urinary bladder smooth muscle, activate adenylate-cyclase. Lysipressin is Antidiuretic hormone that have been found in pigs and some marsupial families. Target: Others. Smiles:...

Description: Aspartame (SC-18862), an artificial, non-carbohydrate sweetener, is aspartyl-phenylalanine-1-methyl ester. Target: Taste receptor, Others. Smiles: [C@@H](CC1=CC=CC=C1)(NC([C@H](CC(O)=O)N)=O)C(OC)=O. References: Xu H, et al. Proc Natl Acad Sci U S A. 2004 Sep 28,101(39):14258-63.

Description: Diprotin A (TFA) is an inhibitor of dipeptidyl peptidase IV (DPP-IV). Target: Others. Smiles: OC(=O)C(F)(F)F.CC[C@H](C)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(O)=O. References: Lee CS, et al. Dipeptidyl Peptidase-4 Inhibitor Increases Vascular Leakage in Retina through VE-cadherin...

Description: Disitertide (P144) is an inhibitor of TGF-beta1. Target: Others. Smiles:...

Description: Disitertide acetate (P144 acetate) is a peptidic transforming growth factor-beta 1 (TGF-beta1) inhibitor specifically designed to block the interaction with its receptor. Disitertide acetate is also a PI3K inhibitor and an apoptosis inducer. Target: TGF-beta/Smad. Smiles:...

Description: Endomorphin 2 TFA, displays reasonable affinities for kappa3 binding sites, with Ki value between 20 and 30 nM. a high affinity, highly selective agonist of the µ-opioid receptor,. Target: Opioid Receptor. Smiles:...