3,3',5'-Triiodo-L-thyronine

3,3',5'-Triiodo-L-thyronine, also known as reverse T3 (rT3), is a thyroid hormone generated by deiodination of the prohormone thyroxine. It is about 1,000-fold less active at the thyroid hormone receptors TRalpha and TRbeta than 3,3',5-triiodo-L-thyronine (Cay-16028) and commonly described as inactive. However, high serum levels of rT3 are found in neonates and in certain conditions. It reportedly activates TRDeltaalpha1, a native form of TRalpha that lacks a nuclear localization signal and functions in the cytoplasm. Through this action, rT3 initiates actin polymerization, particularly in astrocytes and neurons.Formal Name: O-(4-hydroxy-3,5-diiodophenyl)-3-iodo-L-tyrosine. CAS Number: 5817-39-0. Synonyms: Reverse T3, rT3, 3,3',5'-T3. Molecular Formula: C15H12I3NO4. Formula Weight: 651.0. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml. lambdamax: 211, 290 nm. SMILES: IC1=C(O)C(I)=CC(OC2=CC=C(C[C@H](N)C(O)=O)C=C2I)=C1. InChi Code: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)/t12-/m0/s1. InChi Key: HZCBWYNLGPIQRK-LBPRGKRZSA-N.