2-(1-Piperazinyl)pyrimidine

2-(1-Piperazinyl)pyrimidine is an antagonist of alpha2-adrenergic receptors (alpha2-ARs, pA2 = 6.8 in rat brain synaptosomes) and active metabolite of various azapirones, including buspirone. It is formed from buspirone by the cytochrome P450 (CYP) isoform CYP3A4 in human liver microsomes. 2-(1-Piperazinyl)pyrimidine inhibits decreases in gastrointestinal transit induced by clonidine (Cay-15949) in rats (ED50 = 0.8 mg/kg). It increases drinking in the Vogel punished drinking task, indicating anxiolytic-like activity, in rats when administered at doses ranging from 1 to 4 mg/kg. 2-(1-Piperazinyl)pyrimidine (0.25-1 mg/kg) also reduces the amplitude of electrically stimulated excitatory post-synaptic potentials (EPSPs) in the hippocampal CA1 region in rats, an effect that can be blocked by the serotonin (5-HT) receptor subtype 5-HT1A antagonist spiroxatrine. It has also been used a phosphopeptide derivatization agent.CAS Number: 20980-22-7. Synonyms: PmP, 1-PP, 1-(2-Pyrimidyl)piperazine. Molecular Formula: C8H12N4. Formula Weight: 164.2. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 247 nm. SMILES: C1(N2CCNCC2)=NC=CC=N1. InChi Code: InChI=1S/C8H12N4/c1-2-10-8(11-3-1)12-6-4-9-5-7-12/h1-3,9H,4-7H2. InChi Key: MRBFGEHILMYPTF-UHFFFAOYSA-N.