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![Tumor necrosis factor ligand superfamily member 18 protein (TNFSF18), partial (Active), human, recom](https://www.biomol.com/media/image/66/2b/67/CSB-AP002351HU-5_600x600.png)
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You can also order by e-mail: info@biomol.com
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Organism: Homo sapiens (Human). Source: E.Coli. Expression Region: 74-199aa. Protein Length:... more
Product information "Tumor necrosis factor ligand superfamily member 18 protein (TNFSF18), partial (Active), human, recom"
Organism: Homo sapiens (Human). Source: E.Coli. Expression Region: 74-199aa. Protein Length: Partial. Tag Info: Tag-Free. Target Protein Sequence: ETAKEPCMAK FGPLPSKWQM ASSEPPCVNK VSDWKLEILQ NGLYLIYGQV APNANYNDVA PFEVRLYKNK DMIQTLTNKS KIQNVGGTYE LHVGDTIDLI FNSEHQVLKN NTYWGIILLA NPQFIS. Purity: >98% as determined by SDS-PAGE. Endotoxin: Less than 1.0 EU/µg as determined by LAL method. Biological Activity: Fully biologically active when compared to standard. The biological activity as determined by stimulation of IL-8 production using human PBMC is in a concentration range of 0.1-10 ng/ml. Form: Lyophilized powder. Buffer: Lyophilized from a 0.2 µm filtered PBS, pH 7.4. Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20 °C/-80 °C. Our default final concentration of glycerol is 50%. Customers could use it as reference. Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 °C/-80 °C. The shelf life of lyophilized form is 12 months at -20 °C/-80 °C. Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 °C for up to one week. Relevance: Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity). {ECO:0000250, UniProtKB:Q7TS55, ECO:0000269, PubMed:17449724, ECO:0000269, PubMed:18040044, ECO:0000269, PubMed:23892569}. Reference: n/a. Function: Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1
Keywords: | AITRL, hGITRL, TNFSF18, Activation-inducible TNF-related ligand, Glucocorticoid-induced TNF-related ligand, Tumor necrosis factor ligand superfamily member 18, Recombinant Human Tumor necrosis factor ligand superfamily member 18 protein (TNFSF18), partial |
Supplier: | Cusabio |
Supplier-Nr: | AP002351HU |
Properties
Application: | Active protein |
Conjugate: | No |
Species reactivity: | human |
MW: | 14.3 kD |
Purity: | >98% (SDS-PAGE) |
Format: | Lyophilized |
Database Information
KEGG ID : | K05479 | Matching products |
UniProt ID : | Q9UNG2 | Matching products |
Gene ID | GeneID 8995 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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