Mouse Noggin Protein

Recombinant Mouse Noggin Protein is expressed from HEK293 with His tag and Flag tag at the N-Terminus.It contains Gln28-Cys232. Noggin is an antagonist of bone morphogenetic proteins (BMP), being indispensable for certain developmental events.Noggin expression positively correlated with EGFR expression in both GC cell line models and The Cancer Genome Atlas human GC cohort. Targeting EGFR and its downstream pathways diminished cell proliferation which was promoted by Noggin. Noggin promotes the proliferation of GC cells by upregulating EGFR and enhancing a vicious circle formed by beta-catenin, EGFR, ERK and Akt.