Interferon-gamma, equine recombinant (reIFN gamma)

Recombinant equine Interferon-gamma produced in E. coli is a single, non-glycosylated, polypeptide chain containing 143 amino acids and having a molecular mass of 16.7 kDa. IFN-gamma produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions, it is a potent activator of macrophages, and has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. The ED50 as determined by an anti-viral assay using human HeLa cells infected with encephalomyocarditis (EMC) virus is less than 10.0 ng/ml, corresponding to a specific activity of > 1.0 × 105 IU/mg.