Insulin-Like Growth Factor-I, rat recombinant (rrIGF-1)

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake (By similarity). (www.uniprot.org) Produced in E.coli. Single, non-glycosylated, polypeptide chain, 70 amino acids. ED50: 1. Stimulation of protein synthesis in rat L6 myoblasts ED50 was found to be < 30 ng/ml. 2. Type 1 IGF receptor binding assay ED50 was found to be < 10 ng/ml.