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![IL-33 (human, rec.) (His)](https://www.biomol.com/media/image/29/99/77/AG-40A-0042-C010_600x600.png)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
AG-40A-0042-C010 | 10 µg | - |
3 - 9 business days* |
149.00€
|
|||
AG-40A-0042-C050 | 50 µg | - |
3 - 9 business days* |
440.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Human IL-33 (amino acids 112-270) is fused at the C-terminus to a His-tag. Activates human... more
Product information "IL-33 (human, rec.) (His)"
Human IL-33 (amino acids 112-270) is fused at the C-terminus to a His-tag. Activates human ST2-dependent NF-kappaB pathway. Liquid. 0.2µm-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 150mM NaCl. Interleukin-33 (IL-33, HF-NEV, IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The 30kDa human IL33 is converted by CASP1 to a 18kDa protein. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1 (MAPK3)/ERK2 (MAPK1), p38 (MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.
Keywords: | Interleukin-33, IL-1F11, NF-HEV |
Supplier: | AdipoGen Life Sciences |
Supplier-Nr: | AG-40A-0042 |
Properties
Application: | Bioassays |
Conjugate: | No |
Host: | E.coli |
Species reactivity: | human |
MW: | 18 kD |
Format: | Liquid |
Database Information
KEGG ID : | K12967 | Matching products |
UniProt ID : | O95760 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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