IL-21 Protein (Sumo Tag) (recombinant mouse)

Sequence: His18-Ser146. Fusion tag: N-Sumo Endotoxin: < 1.0 EU per µg of the protein as determined by the LAL method Observed Molecular Mass: 35 kDa. Protein function: Interleukin-21 (IL-21) and its receptor appear to play important roles in the regulation of the immune system. IL-21 is most related to IL-2, IL-4, and IL-15. IL-21 R, also called NILR (novel interleukin receptor), is a type I cytokine receptor with 4?conserved cysteine residues and an extracellular WSXWS motif. It is most closely related to IL-2 R beta and IL-4 R alpha. Mouse IL-21 is a 146 amino acid (aa) residue protein with a 24 aa signal peptide. Mouse and human IL-21 share 57% amino acid sequence?identity. IL?21 is expressed by activated T?cells. Although not fully elucidated, the IL-2 R gamma ( gamma c) chain appears to play a role in IL-21 R signaling. The IL?21/IL?21?R interaction appear to play important roles in B and T?cell proliferation after antigen stimulation and NK?cell maturation. Protein function: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (PubMed:15100251). Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection (PubMed:23045607). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15 (PubMed:11970879). May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (PubMed:12893770). [The UniProt Consortium]