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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
E-PDER100135.20 | 20 µg | - | - |
7 - 16 business days* |
248.00€
|
||
E-PDER100135.100 | 100 µg | - | - |
7 - 16 business days* |
742.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Sequence: His18-Ser146. Fusion tag: N-Gst Endotoxin: < 10 EU per mg of the protein as determined... more
Product information "IL-21 Protein (Gst Tag) (recombinant rat)"
Sequence: His18-Ser146. Fusion tag: N-Gst Endotoxin: < 10 EU per mg of the protein as determined by the LAL method Observed Molecular Mass: 45 kDa. Protein function: IL-21 belongs to the IL-15/IL-21 family. It is a cytokine with immunoregulatory activity. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. IL-21 is expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes. It may promote the transition between innate and adaptive immunity. IL-21 has been tried as a therapy for alleviating allergic responses. It can significantly decrease pro-inflammatory cytokines produced by T cells in addition to decreasing IgE levels in a mouse model for rhinitis (nasal passage inflammation). Protein function: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. [The UniProt Consortium]
Keywords: | Il21, IL-21, Interleukin-21, Recombinant Rat IL-21 Protein(Gst Tag) |
Supplier: | Elabscience |
Supplier-Nr: | E-PDER100135 |
Properties
Conjugate: | No |
Host: | E.coli |
Species reactivity: | rat |
Purity: | >90% (SDS-PAGE) |
Format: | Lyophilized |
Database Information
KEGG ID : | K05434 | Matching products |
UniProt ID : | A3QPB9 | Matching products |
Gene ID : | GeneID 365769 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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