IL-10, Mouse

IL-10, Mouse
Item number Size Datasheet Manual SDS Delivery time Quantity Price
CR-C02011-5UG 5 µg - -

10 - 14 business days*

108.00€
CR-C02011-20UG 20 µg - -

10 - 14 business days*

268.00€
CR-C02011-100UG 100 µg - -

10 - 14 business days*

528.00€
CR-C02011-1MG 1 mg - -

10 - 14 business days*

3,480.00€
 
Sequence: MSRGQYSRED NNCTHFPVGQ SHMLLELRTA FSQVKTFFQT KDQLDNILLT DSLMQDFKGY LGCQALSEMI QFYLVEVMPQ... more
Product information "IL-10, Mouse"
Sequence: MSRGQYSRED NNCTHFPVGQ SHMLLELRTA FSQVKTFFQT KDQLDNILLT DSLMQDFKGY LGCQALSEMI QFYLVEVMPQ AEKHGPEIKE LNSLGEKLKT LRMRLRRCHR FLPCENKSKA VEQVKSDFNK LQDQGVYKAM NEFDIFINCI with polyhistidine tag at the C-terminus Endotoxin level: <0.1 EU per 1 µg of the protein by the LAL method. Protein function: Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation. In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (PubMed:28473584). [The UniProt Consortium]
Keywords: Il10, CSIF, Il-10, IL-10, Interleukin-10, Cytokine synthesis inhibitory factor
Supplier: Croyez
Supplier-Nr: C02011

Properties

Application: Cell culture
Conjugate: No
Host: E.coli
Species reactivity: mouse
Purity: >98% (SDS-PAGE)
Format: Lyophilized

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: °C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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